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ErbB2/Her2 antibody (N-Term)

Name: ErbB2/Her2 antibody (N-Term)
SKU: ABIN391945
Price: 451 USD
Availability: InStock

ErbB2/Her2 Reactivity: Human WB, FACS, IHC (p) Host: Rabbit Polyclonal RB01464 unconjugated

Western blot analysis of ErbB2 (arrow) in T47D cell lysates, either noninduced (Lane 1) or induced with HRG (Lane 2). (ErbB2/Her2 antibody (N-Term))

Flow cytometric analysis of MCF-7 cells using HER2/ErbB2 Antibody (N-term) (bottom histogram) compared to a negative control (top histogram). (ErbB2/Her2 antibody (N-Term))

FACS

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. (ErbB2/Her2 antibody (N-Term))

IHC (p)

Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with HER2/ErbB2 antibody (N-term) (ABIN391945 and ABIN2841744) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. (ErbB2/Her2 antibody (N-Term))

IHC (p)

4 images

Catalog No. ABIN391945

Datasheet as PDF

Target See all ErbB2/Her2 Antibodies

ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
Binding Specificity
32

29

26

25

25

23

17

17

15

13

12

7

6

5

5

5

5

4

4

4

4

4

4

4

3

3

3

3

3

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2
AA 21-52, N-Term
Reactivity
419

125

120

32

8

5

3

3

3

2

1

1

1

1

1

1

1

1

1
Human
Host
280

148

10

6

3

2
Rabbit
Compatible Secondaries
Clonality
279

167

2
Polyclonal
Conjugate
272

20

17

8

8

8

8

8

8

8

8

8

8

7

7

4

4

4

4

4

4

3

3

3

3

3

3

3

1
This ErbB2/Her2 antibody is un-conjugated
Application
278

133

96

93

93

87

80

60

54

52

30

20

12

9

8

6

5

4

3

3

2

1

1

1

1

1

1

1

1
Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Predicted Reactivity

M, Rat

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen

This ERBB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21-52 amino acids from the N-terminal region of human ERBB2.

Clone

RB01464

Isotype

Ig Fraction

Top Product

Discover our top product ErbB2/Her2 Primary Antibody
anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 23-372) antibody
ErbB2/Her2 Reactivity: Human WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated

anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (pTyr877) antibody
ErbB2/Her2 Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, IP, ICC Host: Rabbit Polyclonal unconjugated

anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (pTyr1248) antibody
ErbB2/Her2 Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated

anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (pTyr1112) antibody
ErbB2/Her2 Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated

anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (C-Term) antibody
ErbB2/Her2 Reactivity: Human, Mouse, Rat, Dog, Monkey, Horse, Pig, Cow, Rabbit, Hamster, Avian, Cat, Chicken, Donkey, Goat, Guinea Pig, Sheep WB Host: Goat Polyclonal unconjugated

anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 22-121) antibody
ErbB2/Her2 Reactivity: Human WB, ELISA, IF, IHC (p), PLA Host: Mouse Monoclonal 3B1 unconjugated

anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (C-Term) antibody
ErbB2/Her2 Reactivity: Human WB, IHC Host: Rabbit Polyclonal unconjugated

anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 311-462) antibody
ErbB2/Her2 Reactivity: Human IHC, StM Host: Mouse Monoclonal ERBB2-2452 unconjugated

anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 311-462) antibody
ErbB2/Her2 Reactivity: Human IHC, StM Host: Mouse Monoclonal ERBB2-3078 unconjugated

anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (C-Term) antibody
ErbB2/Her2 Reactivity: Human IHC (p), IHC (fro) Host: Rabbit Monoclonal A24-V unconjugated

Application Notes

WB: 1:1000. IHC-P: 1:50~100. IHC-P: 1:50~100. FC: 1:10~50

Restrictions

For Research Use only
Format

Liquid

Buffer

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative

Sodium azide

Precaution of Use

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage

4 °C,-20 °C

Storage Comment

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date

6 months
Target

ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Alternative Name

ErbB2 (ErbB2/Her2 Products)

Background

ErbB2, a member of the EGF receptor family, is an essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. This protein is not activated by EGF, TGF-alpha and amphiregulin. ErbB2 potentially forms a heterodimer with each of the other ERBB receptors. An Interaction with PRKCABP has been suggested. Ligand-binding to this Type I membrane protein may increase phosphorylation on tyrosine residues

Molecular Weight

137910

Gene ID

2064

NCBI Accession

NP_001005862, NP_004439

UniProt

P04626

Pathways

RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development