EPH Receptor A5 antibody (C-Term)

Catalog No. ABIN391893

Product Details anti-EPH Receptor A5 Antibody

Target: EPH Receptor A5 (EPHA5)

Binding Specificity: AA 942-972, C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EPH Receptor A5 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This EphA5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 942-972 amino acids from the C-terminal region of human EphA5.

Clone: RB1658

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-EPH Receptor A5 antibody (ABIN391893)

Wang, Xu, Wu, Chen, Wang: "Decreased expression of EphA5 is associated with Fuhrman nuclear grade and pathological tumour stage in ccRCC." in: International journal of experimental pathology, Vol. 98, Issue 1, pp. 34-39, (2017) (PubMed).

Target Details for EPH Receptor A5

Target: EPH Receptor A5 (EPHA5)

Alternative Name: EphA5 (EPHA5 Products)

Synonyms: CEK7 antibody, EHK-1 antibody, EHK1 antibody, EK7 antibody, HEK7 antibody, TYRO4 antibody, AI854630 antibody, AW125296 antibody, Cek7 antibody, Ehk1 antibody, Els1 antibody, Hek7 antibody, Rek7 antibody, bsk antibody, Els1. antibody, EPHA5 antibody, EPH receptor A5 antibody, Eph receptor A5 antibody, EPHA5 antibody, epha5 antibody, Epha5 antibody

Background: Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).

Molecular Weight: 114803

Gene ID: 2044

NCBI Accession: NP_004430, NP_872272

UniProt: P54756

Pathways: RTK Signaling