EPH Receptor A4 antibody (C-Term)

Catalog No. ABIN391890

Product Details anti-EPH Receptor A4 Antibody

Target: EPH Receptor A4 (EPHA4)

Binding Specificity: AA 875-904, C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EPH Receptor A4 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This EphA4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 875-904 amino acids from the C-terminal region of human EphA4.

Clone: RB1590

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:2000. WB: 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze-thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

Expiry Date: 6 months

References for anti-EPH Receptor A4 antibody (ABIN391890)

Sun, Qian, Lu, Xu: "Lower and reduced expression of EphA4 is associated with advanced TNM stage, lymph node metastasis, and poor survival in breast carcinoma." in: Pathology international, Vol. 66, Issue 9, pp. 506-10, (2017) (PubMed).

Target Details for EPH Receptor A4

Target: EPH Receptor A4 (EPHA4)

Alternative Name: EphA4 (EPHA4 Products)

Synonyms: HEK8 antibody, SEK antibody, TYRO1 antibody, RGD1560587 antibody, ephe antibody, EPHA4 antibody, Ci-Eph1 antibody, sek antibody, hek8 antibody, rtk1 antibody, tyr01 antibody, 2900005C20Rik antibody, AI385584 antibody, Cek8 antibody, Hek8 antibody, Sek antibody, Sek1 antibody, Tyro1 antibody, rb antibody, XEpha4 antibody, sek-1 antibody, epha4 antibody, pag antibody, EphA4 antibody, apha3 antibody, ek2 antibody, epha3 antibody, sb:cb246 antibody, zek2 antibody, zgc:109882 antibody, EPH receptor A4 antibody, Eph receptor A4 antibody, ephrin receptor epsilon antibody, EPH receptor A4 S homeolog antibody, EPH receptor A4 L homeolog antibody, eph receptor A4a antibody, EPHA4 antibody, Epha4 antibody, ephe antibody, epha4 antibody, epha4.S antibody, epha4.L antibody, epha4a antibody

Background: Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).

Molecular Weight: 109860

Gene ID: 2043

NCBI Accession: NP_004429

UniProt: P54764

Pathways: RTK Signaling