EARS2 antibody (C-Term)

Catalog No. ABIN391828

Product Details anti-EARS2 Antibody

Target: EARS2 (Glutamyl-tRNA Synthetase 2 Mitochondrial (EARS2))

Binding Specificity: AA 495-523, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EARS2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This EARS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 495-523 amino acids from the C-terminal region of human EARS2.

Clone: RB14808

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-EARS2 antibody (ABIN391828)

Boczonadi, Smith, Pyle, Gomez-Duran, Schara, Tulinius, Chinnery, Horvath: "Altered 2-thiouridylation impairs mitochondrial translation in reversible infantile respiratory chain deficiency." in: Human molecular genetics, Vol. 22, Issue 22, pp. 4602-15, (2013) (PubMed).

Target Details for EARS2

Target: EARS2 (Glutamyl-tRNA Synthetase 2 Mitochondrial (EARS2))

Alternative Name: EARS2 (EARS2 Products)

Background: Glutamyl-tRNA synthetase (GluRS or EARS2) a class I aminoacyl-tRNA synthetase (aaRS), is primarily responsible for the glutamylation of tRNAGlu. It is part of the ?minimal set?of seventeen aaRSs found in every living organism and its presence is essential for the viability of cells.

Molecular Weight: 58689

Gene ID: 124454

NCBI Accession: NP_001077083

UniProt: Q5JPH6