PDXK antibody (C-Term)

Catalog No. ABIN391248

Product Details anti-PDXK Antibody

Target: PDXK (Pyridoxal Kinase (PDXK))

Binding Specificity: AA 242-272, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDXK antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This PDXK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 242-272 amino acids from the C-terminal region of human PDXK.

Clone: RB5462

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for PDXK

Target: PDXK (Pyridoxal Kinase (PDXK))

Alternative Name: PDXK (PDXK Products)

Synonyms: C21orf124 antibody, C21orf97 antibody, PKH antibody, PNK antibody, 2310036D04Rik antibody, AA119688 antibody, C77999 antibody, Pdxk antibody, PSPTO5521 antibody, DDBDRAFT_0190079 antibody, DDBDRAFT_0191114 antibody, DDB_0190079 antibody, DDB_0191114 antibody, ATSOS4 antibody, K18L3.1 antibody, K18L3_1 antibody, SALT OVERLY SENSITIVE 4 antibody, pdxk antibody, si:dkey-263m10.2 antibody, si:dz69g10.1 antibody, cb1056 antibody, pdxkl antibody, si:dkey-281i8.2 antibody, wu:fa55a03 antibody, wu:fb10c12 antibody, zgc:101900 antibody, pyridoxal kinase antibody, pyridoxal (pyridoxine, vitamin B6) kinase antibody, Pyridoxal kinase antibody, pfkB-like carbohydrate kinase family protein antibody, pyridoxal (pyridoxine, vitamin B6) kinase b antibody, pyridoxal (pyridoxine, vitamin B6) kinase a antibody, PDXK antibody, Pdxk antibody, pdxY antibody, pdxK antibody, Bphyt_1541 antibody, pykA antibody, Kfla_4736 antibody, Kvar_1290 antibody, Mrub_2507 antibody, BC1002_1103 antibody, Fbal_1661 antibody, Lbys_0710 antibody, Intca_0131 antibody, Deima_3190 antibody, Mesop_1158 antibody, LOC100283562 antibody, pdxk antibody, SOS4 antibody, pdxkb antibody, pdxka antibody

Background: Pyridoxal kinase (PDXK) converts vitamin B6 to pyridoxal-5-phosphate (PLP), an essential cofactor in the intermediate metabolism of amino acids and neurotransmitters. The PDXK gene encodes a 312-amino acid polypeptide, and expression of the cDNA reveals pyridoxal kinase activity. Northern blot analysis revealed that a major 1.5-kb PDXK transcript is expressed in all tissues tested. The expression of PDXK shows circadian oscillations. The expression of Pdxk in mouse liver and brain is regulated by the 3 PAR bZIP transcription factors, Dbp, Hlf, and Tef, which also show circadian oscillations in expression. Mice devoid of all 3 transcription factors show decreased levels of brain PLP, serotonin, and dopamine, and are highly susceptible to frequently lethal generalized spontaneous and audiogenic epilepsies.

Molecular Weight: 35102

Gene ID: 8566

NCBI Accession: NP_003672

UniProt: O00764