PANK2 antibody (AA 180-210)

Catalog No. ABIN391238

Product Details anti-PANK2 Antibody

Target: PANK2 (Pantothenate Kinase 2 (PANK2))

Binding Specificity: AA 180-210

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PANK2 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This PANK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 180-210 amino acids from the Central region of human PANK2.

Clone: RB5487

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for PANK2

Target: PANK2 (Pantothenate Kinase 2 (PANK2))

Alternative Name: PANK2 (PANK2 Products)

Synonyms: ATPANK2 antibody, F10M6.180 antibody, F10M6_180 antibody, pantothenate kinase 2 antibody, PANK2 antibody, C20orf48 antibody, HARP antibody, HSS antibody, NBIA1 antibody, PKAN antibody, 4933409I19Rik antibody, AI642621 antibody, pantothenate kinase 2 antibody, pantothenate kinase 2, mitochondrial antibody, ribonuclease A family member 11 (inactive) antibody, PANK2 antibody, Tsp_01576 antibody, LOC100539295 antibody, Pank2 antibody, RNASE11 antibody

Background: Pantothenate kinase is an essential regulatory enzyme in CoA biosynthesis, catalyzing the cytosolic phosphorylation of pantothenate (vitamin B5), N-pantothenoylcysteine, and pantetheine. CoA is the major acyl carrier, playing a central role in intermediary and fatty acid metabolism. In both yeast and fly, each with only 1 pantothenate kinase gene, the null mutant is inviable. Mutations in PANK2 are the cause of pantothenate kinase-associated neurodegeneration (PKAN), formerly known as Hallervorden-Spatz syndrome (HSS). PKAN is an autosomal recessive neurodegenerative disorder associated with iron accumulation in the brain. Mutations in PANK2 are the cause of hypoprebetalipoproteinemia, acanthocytosis, retinitis pigmentosa, and pallidal degeneration (HARP).

Molecular Weight: 62681

Gene ID: 80025

NCBI Accession: NP_079236, NP_705902, NP_705904

UniProt: Q9BZ23

Pathways: Ribonucleoside Biosynthetic Process