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PANK2 antibody (N-Term)

PANK2 Reactivity: Human WB Host: Rabbit Polyclonal RB5486 unconjugated
Catalog No. ABIN391237
  • Target See all PANK2 Antibodies
    PANK2 (Pantothenate Kinase 2 (PANK2))
    Binding Specificity
    • 15
    • 7
    • 6
    • 6
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 65-95, N-Term
    Reactivity
    • 40
    • 21
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    Human
    Host
    • 49
    • 5
    Rabbit
    Clonality
    • 50
    • 5
    Polyclonal
    Conjugate
    • 21
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PANK2 antibody is un-conjugated
    Application
    • 43
    • 25
    • 13
    • 13
    • 7
    • 7
    • 5
    • 3
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This PANK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 65-95 amino acids from the N-terminal region of human PANK2.
    Clone
    RB5486
    Isotype
    Ig Fraction
    Top Product
    Discover our top product PANK2 Primary Antibody
  • Application Notes
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Target
    PANK2 (Pantothenate Kinase 2 (PANK2))
    Alternative Name
    PANK2 (PANK2 Products)
    Synonyms
    ATPANK2 antibody, F10M6.180 antibody, F10M6_180 antibody, pantothenate kinase 2 antibody, PANK2 antibody, C20orf48 antibody, HARP antibody, HSS antibody, NBIA1 antibody, PKAN antibody, 4933409I19Rik antibody, AI642621 antibody, pantothenate kinase 2 antibody, pantothenate kinase 2, mitochondrial antibody, ribonuclease A family member 11 (inactive) antibody, PANK2 antibody, Tsp_01576 antibody, LOC100539295 antibody, Pank2 antibody, RNASE11 antibody
    Background
    Pantothenate kinase is an essential regulatory enzyme in CoA biosynthesis, catalyzing the cytosolic phosphorylation of pantothenate (vitamin B5), N-pantothenoylcysteine, and pantetheine. CoA is the major acyl carrier, playing a central role in intermediary and fatty acid metabolism. In both yeast and fly, each with only 1 pantothenate kinase gene, the null mutant is inviable. Mutations in PANK2 are the cause of pantothenate kinase-associated neurodegeneration (PKAN), formerly known as Hallervorden-Spatz syndrome (HSS). PKAN is an autosomal recessive neurodegenerative disorder associated with iron accumulation in the brain. Mutations in PANK2 are the cause of hypoprebetalipoproteinemia, acanthocytosis, retinitis pigmentosa, and pallidal degeneration (HARP).
    Molecular Weight
    62681
    Gene ID
    80025
    NCBI Accession
    NP_079236, NP_705902, NP_705904
    UniProt
    Q9BZ23
    Pathways
    Ribonucleoside Biosynthetic Process
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