NME3 antibody (AA 51-81)

Catalog No. ABIN391232

Product Details anti-NME3 Antibody

Target: NME3 (NME/NM23 Nucleoside Diphosphate Kinase 3 (NME3))

Binding Specificity: AA 51-81

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NME3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This NME3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 51-81 amino acids from the Central region of human NME3.

Clone: RB5454

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for NME3

Target: NME3 (NME/NM23 Nucleoside Diphosphate Kinase 3 (NME3))

Alternative Name: NME3 (NME3 Products)

Synonyms: DR-nm23 antibody, NDPK-C antibody, NDPKC antibody, NM23-H3 antibody, NM23H3 antibody, c371H6.2 antibody, 1810009F08Rik antibody, AI413736 antibody, Ndk3 antibody, Nm23-DR antibody, Nm23-M3 antibody, NME/NM23 nucleoside diphosphate kinase 3 antibody, NME3 antibody, Nme3 antibody

Background: NME3 mRNA is preferentially expressed at early stages of myeloid differentiation of highly purified CD34(+) cells. Its constitutive expression in a myeloid precursor line, which is growth-factor dependent for both proliferation and differentiation, results in inhibition of granulocytic differentiation induced by granulocyte colony-stimulating factor and causes apoptotic cell death. These results appear consistent with a role for the NME3 gene in normal hematopoiesis and raise the possibility that its overexpression contributes to differentiation arrest, a feature of blastic transformation in chronic myelogenous leukemia.

Molecular Weight: 19015

Gene ID: 4832

NCBI Accession: NP_002504

UniProt: Q13232

Pathways: Nucleotide Phosphorylation, Ribonucleoside Biosynthetic Process