DTYMK antibody (C-Term)

Catalog No. ABIN391075

Product Details anti-DTYMK Antibody

Target: DTYMK (Deoxythymidylate Kinase (Thymidylate Kinase) (DTYMK))

Binding Specificity: AA 164-194, C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DTYMK antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This DTYMK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 164-194 amino acids from the C-terminal region of human DTYMK.

Clone: RB5576

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for DTYMK

Target: DTYMK (Deoxythymidylate Kinase (Thymidylate Kinase) (DTYMK))

Alternative Name: DTYMK (DTYMK Products)

Background: Thymidylate kinase (DTYMK) catalyzes the phosphorylation of dTMP to form dTDP in the dTTP synthesis pathway for DNA synthesis. DTYMK is essential for DNA synthesis and is an important intermediate enzyme in the pathway of many pyrimidine analog drugs, including 5-Fluorouracil (5-FU), the chemotherapeutic drug of choice for several solid tumors. The human DTYMK gene was isolated via functional complementation of a Saccharomyces cerevisiae cell cycle mutant, cdc8. DTYMK mRNA levels and enzyme activities are regulated at the level of cell cycle and cell growth pathways.

Molecular Weight: 23819

Gene ID: 1841

NCBI Accession: NP_036277

UniProt: P23919

Pathways: Nucleotide Phosphorylation