DTYMK antibody (C-Term)

Catalog No. ABIN391075

Product Details anti-DTYMK Antibody

Target: DTYMK (Deoxythymidylate Kinase (Thymidylate Kinase) (DTYMK))

Binding Specificity: AA 164-194, C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DTYMK antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This DTYMK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 164-194 amino acids from the C-terminal region of human DTYMK.

Clone: RB5576

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for DTYMK

Target: DTYMK (Deoxythymidylate Kinase (Thymidylate Kinase) (DTYMK))

Alternative Name: DTYMK (DTYMK Products)

Synonyms: tymk antibody, wu:fa12c02 antibody, wu:fb14h07 antibody, wu:ft84f02 antibody, zgc:123174 antibody, DTYMK antibody, MGC81047 antibody, Tb08.28L1.680 antibody, Tb08.10J17.310 antibody, DDBDRAFT_0188698 antibody, DDBDRAFT_0230101 antibody, DDB_0188698 antibody, DDB_0230101 antibody, AU044245 antibody, CDC8 antibody, D10Ertd203e antibody, TMPK antibody, TYPK antibody, Tmk antibody, mtmk antibody, PP3731 antibody, TYMK antibody, deoxythymidylate kinase antibody, deoxythymidylate kinase (thymidylate kinase) antibody, deoxythymidylate kinase S homeolog antibody, thymidylate kinase antibody, dTMP kinase antibody, Dtymk antibody, dtymk antibody, DTYMK antibody, dtymk.S antibody, Tmk antibody, CNC04630 antibody, Tb927.8.3510 antibody, Tb927.8.3910 antibody, Ndas_4954 antibody, Mesil_2461 antibody, Slip_0046 antibody, Trad_0568 antibody, Olsu_1446 antibody, Acear_0042 antibody, Igag_1070 antibody, LOC100195817 antibody

Background: Thymidylate kinase (DTYMK) catalyzes the phosphorylation of dTMP to form dTDP in the dTTP synthesis pathway for DNA synthesis. DTYMK is essential for DNA synthesis and is an important intermediate enzyme in the pathway of many pyrimidine analog drugs, including 5-Fluorouracil (5-FU), the chemotherapeutic drug of choice for several solid tumors. The human DTYMK gene was isolated via functional complementation of a Saccharomyces cerevisiae cell cycle mutant, cdc8. DTYMK mRNA levels and enzyme activities are regulated at the level of cell cycle and cell growth pathways.

Molecular Weight: 23819

Gene ID: 1841

NCBI Accession: NP_036277

UniProt: P23919

Pathways: Nucleotide Phosphorylation