Aurora Kinase C antibody (AA 115-145)

Catalog No. ABIN390979

Product Details anti-Aurora Kinase C Antibody

Target: Aurora Kinase C (AURKC)

Binding Specificity: AA 115-145

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Aurora Kinase C antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Aurora-C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 115-145 amino acids from the Central region of human Aurora-C.

Clone: RB6822

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-Aurora Kinase C antibody (ABIN390979)

Burum-Auensen, Skotheim, Schjølberg, Røislien, Lothe, Clausen: "Spindle proteins are differentially expressed in the various histological subtypes of testicular germ cell tumors." in: Journal of carcinogenesis, Vol. 9, pp. 1, (2010) (PubMed).

Target Details for Aurora Kinase C

Target: Aurora Kinase C (AURKC)

Alternative Name: Aurora-C (AURKC Products)

Synonyms: AURKC antibody, AIE2 antibody, AIK3 antibody, ARK3 antibody, AurC antibody, SPGF5 antibody, STK13 antibody, aurora-C antibody, AIE1 antibody, ARK-3 antibody, IAK3 antibody, Stk13 antibody, aurora kinase C antibody, AURKC antibody, Aurkc antibody

Background: Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases, members of the Ser/Thr protein kinase family, associate with microtubules during chromosome movement and segregation. Aurora kinase C may play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis. This protein is localized to centrosome from anaphase to cytokinesis. Expression is limited to testis in normal cells. Elevated expression levels are seen only in a subset of cancer cells such as HepG2, HuH7 and HeLa cells. Aurora-C expression is maximum at M phase.

Molecular Weight: 35591

Gene ID: 6795

NCBI Accession: NP_001015878, NP_001015879, NP_003151

UniProt: Q9UQB9

Pathways: Cell Division Cycle, Maintenance of Protein Location