This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This DIO1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 30-57 amino acids from the N-terminal region of human DIO1.
5DI antibody, TXDI1 antibody, ITDI1 antibody, D1 antibody, DIOI antibody, Deio1 antibody, cb685 antibody, zgc:92323 antibody, iodothyronine deiodinase 1 antibody, type I iodothyronine deiodinase-like antibody, deiodinase, iodothyronine, type I antibody, deiodinase, iodothyronine type 1 L homeolog antibody, DIO1 antibody, LOC100231867 antibody, Dio1 antibody, dio1.L antibody, dio1 antibody
Background
DIO1 is a thiol-requiring propylthiouracil-sensitive oxidoreductase. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It also degrades both hormones by inner ring deiodination (IRD).