MTMR4 antibody (C-Term)

Catalog No. ABIN390777

Product Details anti-MTMR4 Antibody

Target: MTMR4 (Myotubularin Related Protein 4 (MTMR4))

Binding Specificity: AA 1155-1187, C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MTMR4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This MTMR4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1155-1187 amino acids from the C-terminal region of human MTMR4.

Clone: RB0716

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-MTMR4 antibody (ABIN390777)

Yu, He, Chen, Hao, Yang, Wang, Pan, Tang: "Myotubularin-related protein 4 (MTMR4) attenuates BMP/Dpp signaling by dephosphorylation of Smad proteins." in: The Journal of biological chemistry, Vol. 288, Issue 1, pp. 79-88, (2013) (PubMed).

Yu, Pan, Qin, Chen, Xu, Chen, Tang: "MTMR4 attenuates transforming growth factor beta (TGFbeta) signaling by dephosphorylating R-Smads in endosomes." in: The Journal of biological chemistry, Vol. 285, Issue 11, pp. 8454-62, (2010) (PubMed).

Plant, Correa, Goldenberg, Bain, Batt: "The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4." in: The Biochemical journal, Vol. 419, Issue 1, pp. 57-63, (2009) (PubMed).

Target Details for MTMR4

Target: MTMR4 (Myotubularin Related Protein 4 (MTMR4))

Alternative Name: MTMR4 (MTMR4 Products)

Synonyms: zfyve11 antibody, fyve-dsp2 antibody, FYVE-DSP2 antibody, ZFYVE11 antibody, AA596759 antibody, ESTM44 antibody, mKIAA0647 antibody, myotubularin related protein 4 antibody, myotubularin related protein 4 L homeolog antibody, Mtmr4 antibody, MTMR4 antibody, mtmr4 antibody, mtmr4.L antibody

Background: MTMR, a member of the myotubularin family, encodes an intracellular protein of 1,195 amino acids, and shares approximately 47 % sequence identity with MTMR3, spiking to over 70 % identity in the catalytic domain and the double zinc finger (FYVE) motif. PCR analysis detects expression of MTMR4 in all human tissues examined except lung, small intestine, stomach, salivary gland, adrenal gland, and uterus. Subcellular localization of MTMR4 in transfected HeLa cells showed a perinuclear distribution, similar to that seen with MTMR3. MTMR4 dephosphorylates para-nitrophenylphosphate and phosphatidylinositol 3-phosphate.

Molecular Weight: 133353

Gene ID: 9110

NCBI Accession: NP_004678

UniProt: Q9NYA4

Pathways: Inositol Metabolic Process