XPO1 antibody (C-Term)

Catalog No. ABIN390636

Product Details anti-XPO1 Antibody

Target: XPO1 (Exportin 1 (XPO1))

Binding Specificity: AA 817-846, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This XPO1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Predicted Reactivity: M, Rat

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This XPO1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 817-846 amino acids from the C-terminal region of human XPO1.

Clone: RB19972

Isotype: Ig Fraction

Application Details

Application Notes: IHC-P: 1:50~100. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-XPO1 antibody (ABIN390636)

Sharma, Åkerström, Sharma, Chow, Teow, Abrenica, Booth, Booth, Mirazimi, Lal: "SARS-CoV 9b protein diffuses into nucleus, undergoes active Crm1 mediated nucleocytoplasmic export and triggers apoptosis when retained in the nucleus." in: PLoS ONE, Vol. 6, Issue 5, pp. e19436, (2011) (PubMed).

Target Details for XPO1

Target: XPO1 (Exportin 1 (XPO1))

Alternative Name: XPO1 (XPO1 Products)

Synonyms: CG13387 antibody, CRM1 antibody, Crm1 antibody, DCRM1 antibody, Dmel\\CG13387 antibody, Emb antibody, XPO-1 antibody, XPO1 antibody, Xpo1 antibody, crm1 antibody, dCRM1 antibody, l(2)k16715 antibody, 18.m06600 antibody, DDBDRAFT_0183812 antibody, DDBDRAFT_0234066 antibody, DDB_0183812 antibody, DDB_0234066 antibody, exportin-1 antibody, LOC100220104 antibody, emb antibody, exp1 antibody, Xpo antibody, AA420417 antibody, Exp1 antibody, embargoed antibody, exportin 1 antibody, putative exportin 1 antibody, chromosome region maintenance protein 1 antibody, exportin-1 antibody, exportin 1 (CRM1 homolog, yeast) antibody, exportin 1 S homeolog antibody, emb antibody, cgd3_3060 antibody, Tc00.1047053511725.150 antibody, Tb11.01.5940 antibody, BBOV_II007220 antibody, LMJF_32_1100 antibody, xpo1 antibody, Xpo1 antibody, XPO1 antibody, LOC100165622 antibody, LOC100633509 antibody, xpo1.S antibody

Background: XPO1 mediates leucine-rich nuclear export signal (NES)-dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1.

Molecular Weight: 123386

Gene ID: 7514

NCBI Accession: NP_003391

UniProt: O14980

Pathways: M Phase