SUV420H2/KMT5C antibody (AA 187-214)

Catalog No. ABIN390405

Product Details anti-SUV420H2/KMT5C Antibody

Target: SUV420H2/KMT5C (SUV420H2) (Suppressor of Variegation 4-20 Homolog 2 (SUV420H2))

Binding Specificity: AA 187-214

Reactivity: Mouse, Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SUV420H2/KMT5C antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Predicted Reactivity: Rat

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This SUV4-20H2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 187-214 amino acids of human SUV4-20H2.

Clone: RB19392

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-SUV420H2/KMT5C antibody (ABIN390405)

Boonsanay, Zhang, Georgieva, Kostin, Qi, Yuan, Zhou, Braun: "Regulation of Skeletal Muscle Stem Cell Quiescence by Suv4-20h1-Dependent Facultative Heterochromatin Formation." in: Cell stem cell, Vol. 18, Issue 2, pp. 229-42, (2016) (PubMed).

Target Details for SUV420H2/KMT5C

Target: SUV420H2/KMT5C (SUV420H2) (Suppressor of Variegation 4-20 Homolog 2 (SUV420H2))

Alternative Name: SUV4-20H2 (SUV420H2 Products)

Synonyms: zgc:162876 antibody, KMT5C antibody, BC024816 antibody, Suv4-20h2 antibody, lysine methyltransferase 5C antibody, suppressor of variegation 4-20 homolog 2 (Drosophila) antibody, lysine (K)-specific methyltransferase 5C L homeolog antibody, KMT5C antibody, kmt5c antibody, SUV420H2 antibody, kmt5c.L antibody, Kmt5c antibody

Background: SUV420H2 is a histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. The protein mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2).

Molecular Weight: 52113

Gene ID: 84787

NCBI Accession: NP_116090

UniProt: Q86Y97