ZBTB7B antibody (AA 181-210)

Catalog No. ABIN390349

Product Details anti-ZBTB7B Antibody

Target: ZBTB7B (Zinc Finger and BTB Domain Containing 7B (ZBTB7B))

Binding Specificity: AA 181-210

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZBTB7B antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This ZBTB7B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 181-210 amino acids from the Central region of human ZBTB7B.

Clone: RB13010

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for ZBTB7B

Target: ZBTB7B (Zinc Finger and BTB Domain Containing 7B (ZBTB7B))

Alternative Name: ZBTB7B (ZBTB7B Products)

Synonyms: THPOK antibody, ZBTB15 antibody, ZFP-67 antibody, ZFP67 antibody, ZNF857B antibody, c-KROX antibody, hcKROX antibody, Thpok antibody, Zfp67 antibody, c-Krox antibody, ZBTB7B antibody, zbtb7b antibody, MGC130914 antibody, zinc finger and BTB domain containing 7B antibody, kruppel-related zinc finger protein hcKrox antibody, ZBTB7B antibody, Zbtb7b antibody, zbtb7b antibody

Background: ZBTB7B is a transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. ZBTB7B is a transcriptional repressor of the collagen COL1A1 and COL1A2 genes. It may also function as a repressor of fibronectin and possibly other extracellular matrix genes.

Molecular Weight: 58027

Gene ID: 51043

NCBI Accession: NP_001239335, NP_001243384

UniProt: O15156