AGR2 antibody (AA 95-124)

Catalog No. ABIN390227

Product Details anti-AGR2 Antibody

Target: AGR2 (Anterior Gradient Homolog 2 (Xenopus Laevis) (AGR2))

Binding Specificity: AA 95-124

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AGR2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Predicted Reactivity: Zf, M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This AGR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 95-124 amino acids from the Central region of human AGR2.

Clone: RB13858

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-AGR2 antibody (ABIN390227)

Guo, Chen, Zhu, Yu, Rong, Merugu, Mangukiya, Li: "A humanized monoclonal antibody targeting secreted anterior gradient 2 effectively inhibits the xenograft tumor growth." in: Biochemical and biophysical research communications, Vol. 475, Issue 1, pp. 57-63, (2017) (PubMed).

Guo, Zhu, Yu, Merugu, Mangukiya, Smith, Li, Zhang, Negi, Rong, Cheng, Wu, Li: "Tumor-secreted anterior gradient-2 binds to VEGF and FGF2 and enhances their activities by promoting their homodimerization." in: Oncogene, Vol. 36, Issue 36, pp. 5098-5109, (2017) (PubMed).

Target Details for AGR2

Target: AGR2 (Anterior Gradient Homolog 2 (Xenopus Laevis) (AGR2))

Alternative Name: Anterior Gradient 2 (AGR2) (AGR2 Products)

Background: Anterior gradient 2 (AGR2) is known as a cancer cell marker specifically up-regulated in response to depletion of serum and oxygen. AGR2 has been identified as a tumor marker in primary and secondary cancer lesions, and as a marker for detection of circulating tumor cells (CTCs). Elevated levels of AGR2 are known to increase the metastatic potential of cancer cells, but conditions leading to increased expression of AGR2 are not well understood.

Molecular Weight: 19979

Gene ID: 10551

NCBI Accession: NP_006399

UniProt: O95994