OASL antibody (C-Term)

Catalog No. ABIN390168

Product Details anti-OASL Antibody

Target: OASL (2'-5'-Oligoadenylate Synthetase-Like (OASL))

Binding Specificity: AA 484-514, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OASL antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This OASL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 484-514 amino acids from the C-terminal region of human OASL.

Clone: RB1948

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-OASL antibody (ABIN390168)

Forero, Giacobbi, McCormick, Gjoerup, Bakkenist, Pipas, Sarkar: "Simian virus 40 large T antigen induces IFN-stimulated genes through ATR kinase." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 192, Issue 12, pp. 5933-42, (2014) (PubMed).

Forero, Moore, Sarkar: "Role of IRF4 in IFN-stimulated gene induction and maintenance of Kaposi sarcoma-associated herpesvirus latency in primary effusion lymphoma cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 191, Issue 3, pp. 1476-85, (2013) (PubMed).

Ishibashi, Wakita, Esumi: "2',5'-Oligoadenylate synthetase-like gene highly induced by hepatitis C virus infection in human liver is inhibitory to viral replication in vitro." in: Biochemical and biophysical research communications, Vol. 392, Issue 3, pp. 397-402, (2010) (PubMed).

Target Details for OASL

Target: OASL (2'-5'-Oligoadenylate Synthetase-Like (OASL))

Alternative Name: OASL (OASL Products)

Synonyms: Oasl1 antibody, oasl9 antibody, 7530414C13Rik antibody, OASLd antibody, TRIP-14 antibody, TRIP14 antibody, p59 OASL antibody, p59-OASL antibody, p59OASL antibody, 2'-5'-oligoadenylate synthetase-like antibody, 2'-5' oligoadenylate synthetase-like 1 antibody, 2'-5'-oligoadenylate synthetase like antibody, 2'-5'-oligoadenylate synthase-like protein antibody, Oasl antibody, Oasl1 antibody, OASL antibody, LOC100356242 antibody, LOC100483471 antibody

Background: 2-prime,5-prime oligoadenylates (2-5As) bind to and activate RNase L, leading to degradation of RNA and inhibition of protein synthesis. 2-5As are produced by 2-5A synthetases (OASs), a highly-conserved family of interferon-induced enzymes. The predicted 514-amino acid human p59OASL (2-5A synthetases-like) protein shares a highly conserved N-terminal domain with other OASs. The C-terminal portion of p59OASL contains 2 ubiquitin-like domains. p59OASL is expressed in most tissues, with the highest levels in hematopoietic tissues, colon, and stomach.

Molecular Weight: 59226

Gene ID: 8638

NCBI Accession: NP_001248754, NP_003724, NP_937856

UniProt: Q15646