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EDG4 antibody (N-Term)

LPAR2 Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal RB1827 unconjugated
Catalog No. ABIN390085
  • Target See all EDG4 (LPAR2) Antibodies
    EDG4 (LPAR2) (Lysophosphatidic Acid Receptor 2 (LPAR2))
    Binding Specificity
    • 16
    • 7
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 3-32, N-Term
    Reactivity
    • 41
    • 27
    • 21
    • 2
    Human
    Host
    • 56
    • 1
    Rabbit
    Clonality
    • 57
    Polyclonal
    Conjugate
    • 25
    • 4
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This EDG4 antibody is un-conjugated
    Application
    • 24
    • 22
    • 15
    • 13
    • 13
    • 11
    • 9
    • 7
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Predicted Reactivity
    Pr
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This EDG4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3-32 amino acids from the N-terminal region of human EDG4.
    Clone
    RB1827
    Isotype
    Ig Fraction
  • Application Notes
    WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Yamauchi, Yamamura, Katase, Itadani, Okada, Kobiki, Nakamura, Yamaguchi, Kuribayashi: "Evaluation of pancreatic cancer cell migration with multiple parameters in vitro by using an optical real-time cell mobility assay device." in: BMC cancer, Vol. 17, Issue 1, pp. 234, (2017) (PubMed).

    Geng, Lan, Singha, Gilchrist, Weinreb, Violette, Weinberg, Saikumar, Venkatachalam: "Lysophosphatidic acid increases proximal tubule cell secretion of profibrotic cytokines PDGF-B and CTGF through LPA2- and G?q-mediated Rho and ?v?6 integrin-dependent activation of TGF-?." in: The American journal of pathology, Vol. 181, Issue 4, pp. 1236-49, (2012) (PubMed).

    Bernhart, Kollroser, Rechberger, Reicher, Heinemann, Schratl, Hallström, Wintersperger, Nusshold, DeVaney, Zorn-Pauly, Malli, Graier, Malle, Sattler: "Lysophosphatidic acid receptor activation affects the C13NJ microglia cell line proteome leading to alterations in glycolysis, motility, and cytoskeletal architecture." in: Proteomics, Vol. 10, Issue 1, pp. 141-58, (2010) (PubMed).

    Todorova, Fuentes, Soria, Nadal, Quesada: "Lysophosphatidic acid induces Ca2+ mobilization and c-Myc expression in mouse embryonic stem cells via the phospholipase C pathway." in: Cellular signalling, Vol. 21, Issue 4, pp. 523-8, (2009) (PubMed).

    Horak, Lee, Elkahloun, Boissan, Dumont, Maga, Arnaud-Dabernat, Palmieri, Stetler-Stevenson, Lacombe, Meltzer, Steeg: "Nm23-H1 suppresses tumor cell motility by down-regulating the lysophosphatidic acid receptor EDG2." in: Cancer research, Vol. 67, Issue 15, pp. 7238-46, (2007) (PubMed).

  • Target
    EDG4 (LPAR2) (Lysophosphatidic Acid Receptor 2 (LPAR2))
    Alternative Name
    EDG4 (LPAR2 Products)
    Synonyms
    EDG-4 antibody, EDG4 antibody, LPA-2 antibody, LPA2 antibody, lpa2 antibody, Gpbar1 antibody, Edg4 antibody, IPA2 antibody, Pbx4 antibody, RGD1561336 antibody, zgc:101053 antibody, lysophosphatidic acid receptor 2 antibody, lysophosphatidic acid receptor 2 S homeolog antibody, G protein-coupled bile acid receptor 1 antibody, growth hormone releasing hormone receptor antibody, lysophosphatidic acid receptor 2a antibody, LPAR2 antibody, lpar2.S antibody, GPBAR1 antibody, Lpar2 antibody, GHRHR antibody, lpar2a antibody
    Background
    EDG4 is a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins.
    Molecular Weight
    39084
    Gene ID
    9170
    NCBI Accession
    NP_004711
    UniProt
    Q9HBW0
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