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EPR1 antibody (C-Term)

EPR1 Reactivity: Human WB Host: Rabbit Polyclonal RB1796 unconjugated
Catalog No. ABIN390071
  • Target See all EPR1 Antibodies
    EPR1 (Early-Phytochrome-Responsive1 (EPR1))
    Binding Specificity
    AA 308-337, C-Term
    Reactivity
    Human
    Host
    • 18
    Rabbit
    Clonality
    • 18
    Polyclonal
    Conjugate
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This EPR1 antibody is un-conjugated
    Application
    • 18
    • 13
    • 3
    • 2
    • 1
    Western Blotting (WB)
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This EPR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-337 amino acids from the C-terminal region of human EPR1.
    Clone
    RB1796
    Isotype
    Ig Fraction
  • Application Notes
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Target
    EPR1 (Early-Phytochrome-Responsive1 (EPR1))
    Alternative Name
    EPR1 (EPR1 Products)
    Background
    Cellular receptors for blood proteases regulate chemotaxis, extracellular proteolysis, and growth behavior of normal and malignant cells. Effector cell protease receptor-1 (EPR1) is a receptor for the coagulation protease factor Xa. EPR1 is characterized by a cysteine-rich extracellular module, a single membrane-spanning domain, and a serine-rich cytoplasmic tail featuring at least 15 potential phosphorylation sites. EPR1 also contains 2 N-linked glycosylation sites, 4 O-linked glycosylation sites, and a chondroitin sulfate attachment site, which may provide anchoring for carbohydrate chains, EPR1 transfectants bind to factor Xa in a specific and saturable manner, and in the absence of factor V/Va promote prothrombin activation in a factor Xa concentration-dependent reaction. Activated platelets and megakaryocytes express EPR1. Both EPR1 and membrane-bound factor Va are thought to be required to mediate factor Xa binding to the activated platelet to form a functional prothrombinase complex.
    Molecular Weight
    36826
    UniProt
    Q14868
    Pathways
    Apoptosis, Cell Division Cycle
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