Insulin Receptor antibody (pTyr1185)
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- Target See all Insulin Receptor (INSR) Antibodies
- Insulin Receptor (INSR)
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Binding Specificity
- pTyr1185
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Insulin Receptor antibody is un-conjugated
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Application
- Dot Blot (DB)
- Predicted Reactivity
- B, M, Rat, X, D
- Purification
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- Immunogen
- This INSR Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1185 of human INSR.
- Clone
- RB15377
- Isotype
- Ig Fraction
- Top Product
- Discover our top product INSR Primary Antibody
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anti-Insulin Receptor (INSR) antibody
INSR Reactivity: Human WB, IHC, IP, ICC Host: Mouse Monoclonal C19 unconjugated
anti-Insulin Receptor (INSR) (AA 1024-1298) antibodyINSR Reactivity: Human WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Insulin Receptor (INSR) (AA 1027-1364) antibodyINSR Reactivity: Human WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Insulin Receptor (INSR) (AA 1101-1372) antibodyINSR Reactivity: Mouse WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Insulin Receptor (INSR) (AA 27-57), (N-Term) antibodyINSR Reactivity: Human, Mouse WB, IHC (p) Host: Rabbit Polyclonal RB1421 unconjugated
anti-Insulin Receptor (INSR) (C-Term) antibodyINSR Reactivity: Human, Mouse, Rat, Dog, Monkey, Horse, Cow, Guinea Pig, Rabbit, Pig, Chicken, Sheep, Hamster, Avian, Cat, Donkey, Goat WB Host: Goat Polyclonal unconjugated
anti-Insulin Receptor (INSR) (C-Term) antibodyKO Validated INSR Reactivity: Human WB, ICC, IF, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-Insulin Receptor (INSR) (AA 1325-1358) antibodyINSR Reactivity: Mouse WB Host: Rabbit Polyclonal RB50340 unconjugated
anti-Insulin Receptor (INSR) (AA 1023-1298) antibodyINSR Reactivity: Human IHC, ELISA, IF Host: Rabbit Polyclonal unconjugated
anti-Insulin Receptor (INSR) (AA 51-150) antibodyINSR Reactivity: Human, Mouse, Rat WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
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- Application Notes
- DB: 1:500
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
- Expiry Date
- 6 months
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- Target
- Insulin Receptor (INSR)
- Alternative Name
- INSR (INSR Products)
- Background
- Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake, thereby mediating the metabolic functions of insulin. Binding to insulin stimulates association of the receptor with downstream mediators including IRS1 and phosphatidylinositol 3'-kinase (PI3K). This protein can activate PI3K either directly by binding to the p85 regulatory subunit, or indirectly via IRS1. After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked.
- Molecular Weight
- 156333
- Gene ID
- 3643
- NCBI Accession
- NP_000199, NP_001073285
- UniProt
- P06213
- Pathways
- NF-kappaB Signaling, RTK Signaling, AMPK Signaling, Carbohydrate Homeostasis, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Growth Factor Binding, Negative Regulation of Transporter Activity
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