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SMAD4 antibody (pThr277)
SMAD4
Reactivity: Human, Mouse
WB
Host: Rabbit
Polyclonal
RB07971
unconjugated
Product Details anti-SMAD4 Antibody
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Target
See all SMAD4 Antibodies
SMAD4
(SMAD Family Member 4 (SMAD4))
Binding Specificity
All epitopes for SMAD4 antibodies
pThr277
Reactivity
All reactivities for SMAD4 antibodies
Human, Mouse
Host
All hosts for SMAD4 antibodies
Rabbit
Clonality
All clonalities for SMAD4 antibodies
Polyclonal
Conjugate
All conjugates for SMAD4 antibodies
This SMAD4 antibody is un-conjugated
Application
All applications for SMAD4 antibodies
Western Blotting (WB)
Predicted Reactivity
Rat
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This SMAD4 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T277 of human SMAD4.
Clone
RB07971
Isotype
Ig Fraction
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Discover our top product SMAD4 Primary Antibody
Alternatives
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Application Details
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Application Notes
WB: 1:500
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Storage Comment
Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date
6 months
References for anti-SMAD4 antibody (ABIN389658)
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Arjunan, Gnanaprakasam, Ananth, Romej, Rajalakshmi, Prasad, Martin, Gurusamy, Thangaraju, Bhutia, Ganapathy : "Increased Retinal Expression of the Pro-Angiogenic Receptor GPR91 via BMP6 in a Mouse Model of Juvenile Hemochromatosis. " in: Investigative ophthalmology & visual science , Vol. 57 , Issue 4 , pp. 1612-9 , (2016 ) (PubMed ).
Target Details for SMAD4
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Target
SMAD4
(SMAD Family Member 4 (SMAD4))
Alternative Name
SMAD4 (SMAD4 Products )
Background
Common mediator of signal transduction by TGF-beta (transforming growth factor) superfamily, SMAD4 is the common SMAD (co-SMAD). It promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. It may act as a tumor suppressor.
Molecular Weight
60439
Gene ID
4089
NCBI Accession
NP_005350
UniProt
Q13485
Pathways
Cell Division Cycle , Chromatin Binding , Autophagy
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