PFDN6 antibody (N-Term)

Catalog No. ABIN389346

Product Details anti-PFDN6 Antibody

Target: PFDN6 (Prefoldin Subunit 6 (PFDN6))

Binding Specificity: AA 6-34, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PFDN6 antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: B, M

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This PFDN6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-34 amino acids from the N-terminal region of human PFDN6.

Clone: RB17559

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-PFDN6 antibody (ABIN389346)

Tashiro, Zako, Muto, Itoo, Sörgjerd, Terada, Abe, Miyazawa, Kitamura, Kitaura, Kubota, Maeda, Momoi, Iguchi-Ariga, Kinjo, Ariga: "Prefoldin protects neuronal cells from polyglutamine toxicity by preventing aggregation formation." in: The Journal of biological chemistry, Vol. 288, Issue 27, pp. 19958-72, (2013) (PubMed).

Abe, Takahashi-Niki, Takekoshi, Shimizu, Kitaura, Maita, Iguchi-Ariga, Ariga: "Prefoldin plays a role as a clearance factor in preventing proteasome inhibitor-induced protein aggregation." in: The Journal of biological chemistry, Vol. 288, Issue 39, pp. 27764-76, (2013) (PubMed).

Miyazawa, Tashiro, Kitaura, Maita, Suto, Iguchi-Ariga, Ariga: "Prefoldin subunits are protected from ubiquitin-proteasome system-mediated degradation by forming complex with other constituent subunits." in: The Journal of biological chemistry, Vol. 286, Issue 22, pp. 19191-203, (2011) (PubMed).

Target Details for PFDN6

Target: PFDN6 (Prefoldin Subunit 6 (PFDN6))

Alternative Name: PFDN6 (PFDN6 Products)

Synonyms: hke2 antibody, ke-2 antibody, pfd6 antibody, h2-ke2 antibody, pfdn6a antibody, 23.m05913 antibody, H-2Ke2 antibody, Ke-2 antibody, Pfdn6 antibody, H2-KE2 antibody, HKE2 antibody, KE-2 antibody, PFD6 antibody, zgc:66282 antibody, pfdn6 antibody, pfdn6b antibody, Ke2 antibody, prefoldin subunit 6 S homeolog antibody, prefoldin subunit 6 (predicted) antibody, prefoldin subunit 6 antibody, prefoldin subunit 6 L homeolog antibody, pfdn6.S antibody, SPAC3A11.13 antibody, BBOV_IV004800 antibody, AOR_1_2254174 antibody, CMU_042830 antibody, pfdn6 antibody, Pfdn6 antibody, PFDN6 antibody, pfdn6.L antibody

Background: PFDN6 binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. This protein also binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

Molecular Weight: 14583

Gene ID: 10471

NCBI Accession: NP_001172110, NP_001252524, NP_001252525, NP_055075

UniProt: O15212

Pathways: Unfolded Protein Response