SNURF antibody (AA 4-32)

Catalog No. ABIN389318

Product Details anti-SNURF Antibody

Target: SNURF (SNRPN Upstream Reading Frame (SNURF))

Binding Specificity: AA 4-32

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SNURF antibody is un-conjugated

Application: Please inquire

Predicted Reactivity: B, M, Rb

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This SNURF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-32 amino acids from the Central region of human SNURF.

Clone: RB17346

Isotype: Ig Fraction

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for SNURF

Target: SNURF (SNRPN Upstream Reading Frame (SNURF))

Alternative Name: SNURF (SNURF Products)

Synonyms: 2410045I01Rik antibody, Snrpn antibody, SNRPN upstream reading frame antibody, small nuclear ribonucleoprotein polypeptide N antibody, SNURF antibody, SNRPN antibody, Snurf antibody

Background: SNURF is a highly basic protein localized to the nucleus. The evolutionarily constrained open reading frame of its gene is found on a bicistronic transcript which has a downstream ORF encoding the small nuclear ribonucleoprotein polypeptide N. The upstream coding region utilizes the first three exons of the transcript, a region that has been identified as an imprinting center. Multiple transcription initiation sites have been identified and extensive alternative splicing occurs in the 5' untranslated region but the full-length nature of these transcripts has not been determined. An alternate exon has been identified that substitutes for exon 4 and leads to a truncated, monocistronic transcript. Alternative splicing or deletion caused by a translocation event in the 5' UTR or coding region of this gene leads to Angelman syndrome or Prader-Willi syndrome due to parental imprint switch failure. The function of this protein is not yet known.

Molecular Weight: 8412

Gene ID: 8926

NCBI Accession: NP_005669, NP_073715

UniProt: Q9Y675