FOXP3 antibody (C-Term)

Catalog No. ABIN389295

Product Details anti-FOXP3 Antibody

Target: FOXP3 (Forkhead Box P3 (FOXP3))

Binding Specificity: AA 283-311, C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FOXP3 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Predicted Reactivity: Pr

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This FOXP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 283-311 amino acids from the C-terminal region of human FOXP3.

Clone: RB17111

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:10~50. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-FOXP3 antibody (ABIN389295)

Sun, Feng, Wang, Qu, Gai: "Expression of Foxp3 and its prognostic significance in colorectal cancer." in: International journal of immunopathology and pharmacology, Vol. 30, Issue 2, pp. 201-206, (2018) (PubMed).

Zha, Huang, Lin, Liu, Hou, Wu: "Distribution of lymphocyte subpopulations in thyroid glands of human autoimmune thyroid disease." in: Journal of clinical laboratory analysis, Vol. 28, Issue 3, pp. 249-54, (2015) (PubMed).

Liu, Lu, Feng, Ding, Gao, Ge, Wang: "Up-regulated expression of indoleamine 2,3-dioxygenase 1 in non-Hodgkin lymphoma correlates with increased regulatory T-cell infiltration." in: Leukemia & lymphoma, Vol. 55, Issue 2, pp. 405-14, (2014) (PubMed).

Dou, Feng, Liu, Wang: "Cyclic adenosine monophosphate involvement in low-dose cyclophosphamide-reversed immune evasion in a mouse lymphoma model." in: Cellular & molecular immunology, Vol. 9, Issue 6, pp. 482-8, (2013) (PubMed).

Target Details for FOXP3

Target: FOXP3 (Forkhead Box P3 (FOXP3))

Alternative Name: FOXP3 (FOXP3 Products)

Background: FOXP3 is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in FOXP3 gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome.

Molecular Weight: 47244

Gene ID: 50943

NCBI Accession: NP_001107849, NP_054728

UniProt: Q9BZS1

Pathways: Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation