Fibrillarin antibody (AA 105-135)
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- Target See all Fibrillarin (FBL) Antibodies
- Fibrillarin (FBL)
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Binding Specificity
- AA 105-135
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Fibrillarin antibody is un-conjugated
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Application
- Western Blotting (WB)
- Predicted Reactivity
- M, Rat
- Purification
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- Immunogen
- This FBL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 105-135 amino acids from the Central region of human FBL.
- Clone
- RB16515
- Isotype
- Ig Fraction
- Top Product
- Discover our top product FBL Primary Antibody
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- Application Notes
- WB: 1:1000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
- Expiry Date
- 6 months
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- Target
- Fibrillarin (FBL)
- Alternative Name
- FBL (FBL Products)
- Background
- FBL is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. This protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8 % of humans with the autoimmune disease scleroderma recognize fibrillarin.
- Molecular Weight
- 33784
- Gene ID
- 2091
- NCBI Accession
- NP_001427
- UniProt
- P22087
- Pathways
- Ribonucleoside Biosynthetic Process
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