Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Predicted Reactivity
M
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This COL9A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 428-456 amino acids from the Central region of human COL9A1.
cb339 antibody, sb:cb339 antibody, zgc:85892 antibody, wu:fa12a12 antibody, wu:fa12d02 antibody, wu:fc22c08 antibody, wu:fc38d08 antibody, edm6 antibody, MGC82441 antibody, DJ149L1.1.2 antibody, EDM6 antibody, MED antibody, STL4 antibody, Col9a-1 antibody, collagen, type IX, alpha 1b antibody, collagen, type IX, alpha 1 L homeolog antibody, collagen type IX alpha 1 chain antibody, collagen, type IX, alpha 1 antibody, collagen alpha-1(IX) chain antibody, col9a1b antibody, col9a1.L antibody, COL9A1 antibody, Col9a1 antibody, LOC101102992 antibody
Background
COL9A1 is one of the three alpha chains of type IX collagen, which is a minor (5-20 % ) collagen component of hyaline cartilage. Type IX collagen is usually found in tissues containing type II collagen, a fibrillar collagen. Studies in knockout mice have shown that synthesis of the alpha 1 chain is essential for assembly of type IX collagen molecules, a heterotrimeric molecule,and that lack of type IX collagen is associated with early onset osteoarthritis. Mutations in the COL9A1 gene are associated with osteoarthritis in humans, with multiple epiphyseal dysplasia, 6, a form of chondrodysplasia, and with Stickler syndrome, a disease characterized by ophthalmic, orofacial, articular, and auditory defects.