GGPS1 antibody (N-Term)

Catalog No. ABIN389055

Product Details anti-GGPS1 Antibody

Target: GGPS1 (Geranylgeranyl Diphosphate Synthase 1 (GGPS1))

Binding Specificity: AA 16-46, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GGPS1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Predicted Reactivity: B, M, Rat

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This GGPS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-46 amino acids from the N-terminal region of human GGPS1.

Clone: RB4788

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-GGPS1 antibody (ABIN389055)

Iguchi, Katsuno, Niwa, Yamada, Sone, Waza, Adachi, Tanaka, Nagata, Arimura, Watanabe, Kaibuchi, Sobue: "TDP-43 depletion induces neuronal cell damage through dysregulation of Rho family GTPases." in: The Journal of biological chemistry, Vol. 284, Issue 33, pp. 22059-66, (2009) (PubMed).

Target Details for GGPS1

Target: GGPS1 (Geranylgeranyl Diphosphate Synthase 1 (GGPS1))

Alternative Name: GGPS1 (GGPS1 Products)

Background: Geranylgeranyl diphosphate (GGPP) synthase (GGPS) catalyzes the synthesis of GGPP, a molecule responsible for the C20-prenylation of protein and for the regulation of a nuclear hormone receptor. The deduced 300-amino acid human protein contains 5 conserved domains consistent with prenyltransferases. Recombinant GGPS shows enzymatic properties associated with the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. Mouse GGPS is regulated in several tissues in obesity and is induced during adipocyte differentiation. GGPS is increased 5- to 20-fold in skeletal muscle, liver, and fat of ob/ob mice. Western blot analysis detects a 2-fold overexpression of protein in muscle and fat but not in liver. Differentiation of mouse fibroblasts into adipocytes induces GGPS expression more than 20-fold.

Molecular Weight: 34871

Gene ID: 9453

NCBI Accession: NP_001032354

UniProt: O95749