Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

USP33 antibody (C-Term)

USP33 Reactivity: Human WB Host: Rabbit Polyclonal RB4423-4424 unconjugated
Catalog No. ABIN388945
  • Target See all USP33 Antibodies
    USP33 (Ubiquitin Specific Peptidase 33 (USP33))
    Binding Specificity
    • 15
    • 7
    • 6
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 799-829, C-Term
    Reactivity
    • 38
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    Human
    Host
    • 36
    • 2
    Rabbit
    Clonality
    • 36
    • 2
    Polyclonal
    Conjugate
    • 20
    • 4
    • 4
    • 4
    • 3
    • 3
    This USP33 antibody is un-conjugated
    Application
    • 24
    • 21
    • 19
    • 9
    • 6
    • 6
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Predicted Reactivity
    B
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This VDU1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 799-829 amino acids from the C-terminal region of human VDU1.
    Clone
    RB4423-4424
    Isotype
    Ig Fraction
    Top Product
    Discover our top product USP33 Primary Antibody
  • Application Notes
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Target
    USP33 (Ubiquitin Specific Peptidase 33 (USP33))
    Alternative Name
    VDU1 (USP33 Products)
    Synonyms
    USP33 antibody, VDU1 antibody, 9830169D19Rik antibody, AA409780 antibody, Vdu1 antibody, zgc:77308 antibody, ubiquitin specific peptidase 33 antibody, universal stress protein UspA antibody, Usp33 antibody, USP33 antibody, RR_RS17870 antibody, usp33 antibody
    Background
    Type 2 iodothyronine deiodinase (D2) is an integral membrane selenoenzyme that stimulates the pro-hormone thyroxine (T4) and supplies the majority of the 3,5,3?-triiodothyronine (T3) essential for brain development.1 T4 catalysis accelerates selective conjugation to ubiquitin and thereby renders D2 inactive, a posttranslational feedback mechanism used to maintain acceptable T3 levels.2,3 Ub-D2 was the first recognized substrate for von Hippel?Lindau protein?interacting (pVHL-interacting) deubiquitinating enzyme-1 (VDU1).4 VDU proteins colocalize with D2 in the endoplasmic reticulum, and their coexpression provides D2 resistance to degradation. VDU1 expression is substantially upregulated in brown adipocytes by norepinephrine or cold exposure, further amplifying D2 activity. VDU1 and VDU2 are coexpressed with D2 in many human tissues, including brain, heart, and skeletal muscle, suggesting potential roles in neurological development, cardiac function, and energy management, in addition to thermal homeostasis.VDU1- or VDU2-catalyzed deubiquitination recycles inactive Ub-D2 to its active deubiquitinated form, circumventing the proteasomal degradation pathway. Thus, Ub-D2 can be either reactivated or degraded, with the balance between these two processes influenced by VDU activity.VDU1-catalyzed D2 deubiquitination may be an important participant in the adaptive mechanism that regulates thyroid hormone action. The reversible ubiquitination-dependent mechanism regulating D2 activity permits highly responsive control of thyroid hormone activation.5,6
    Molecular Weight
    106727
    Gene ID
    23032
    NCBI Accession
    NP_055832, NP_963918, NP_963920
    UniProt
    Q8TEY7
    Pathways
    Regulation of G-Protein Coupled Receptor Protein Signaling
You are here:
Support