USP16 antibody (AA 386-416)

Catalog No. ABIN388907

Product Details anti-USP16 Antibody

Target: USP16 (Ubiquitin Specific Peptidase 16 (USP16))

Binding Specificity: AA 386-416

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This USP16 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This USP16 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 386-416 amino acids from the Central region of human USP16.

Clone: RB4343-4344

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for USP16

Target: USP16 (Ubiquitin Specific Peptidase 16 (USP16))

Alternative Name: USP16 (USP16 Products)

Synonyms: ubp-m antibody, USP16 antibody, UBP-M antibody, 1200004E02Rik antibody, 2810483I07Rik antibody, 6330514E22Rik antibody, UBPM antibody, si:ch211-238e22.5 antibody, si:dkey-121n8.2 antibody, wu:fc76b02 antibody, wu:fc76b08 antibody, universal stress protein antibody, ubiquitin specific peptidase 16 antibody, ubiquitin specific peptidase 16 L homeolog antibody, usp16 antibody, USP16 antibody, Usp16 antibody, usp16.L antibody

Background: Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.

Molecular Weight: 93570

Gene ID: 10600

NCBI Accession: NP_001001992, NP_001027582, NP_006438

UniProt: Q9Y5T5