USP11 antibody (N-Term)

Catalog No. ABIN388894

Product Details anti-USP11 Antibody

Target: USP11 (Ubiquitin Specific Peptidase 11 (USP11))

Binding Specificity: AA 279-308, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This USP11 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This USP11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 279-308 amino acids from the N-terminal region of human USP11.

Clone: RB4293-4294

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for USP11

Target: USP11 (Ubiquitin Specific Peptidase 11 (USP11))

Alternative Name: USP11 (USP11 Products)

Synonyms: USP11 antibody, DKFZp459L098 antibody, UHX1 antibody, 6230415D12Rik antibody, mKIAA4085 antibody, Uhx1 antibody, ubiquitin specific peptidase 11 antibody, universal stress protein antibody, USP11 antibody, RR_RS19935 antibody, Usp11 antibody

Background: Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.

Molecular Weight: 109817

Gene ID: 8237

NCBI Accession: NP_004642

UniProt: P51784