Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Predicted Reactivity
M, Rat
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Immunogen
This BMPR1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 30-60 amino acids from the N-terminal region of human BMPR1A.
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Storage Comment
Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date
6 months
Peng, Mukhopadhyay, Jarrett, Yoshikawa, Kessler: "BMP receptor 1A regulates development of hypothalamic circuits critical for feeding behavior." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 32, Issue 48, pp. 17211-24, (2012) (PubMed).
Kan, Liu, McGuire, Berger, Awatramani, Dymecki, Kessler: "Dysregulation of local stem/progenitor cells as a common cellular mechanism for heterotopic ossification." in: Stem cells (Dayton, Ohio), Vol. 27, Issue 1, pp. 150-6, (2009) (PubMed).
Mukhopadhyay, McGuire, Peng, Kessler: "Differential effects of BMP signaling on parvalbumin and somatostatin interneuron differentiation." in: Development (Cambridge, England), Vol. 136, Issue 15, pp. 2633-42, (2009) (PubMed).
Target
BMPR1A
(Bone Morphogenetic Protein Receptor 1A (BMPR1A))
10q23del antibody, ACVRLK3 antibody, ALK3 antibody, CD292 antibody, SKR5 antibody, 1110037I22Rik antibody, AU045487 antibody, BMPR-IA antibody, Bmpr antibody, BMPR-1 antibody, BRK-1 antibody, BMPR1A antibody, acvrlk3 antibody, alk-3 antibody, alk3 antibody, cd292 antibody, skr5 antibody, BR1a antibody, alk3tr antibody, bmpr1a antibody, zgc:136731 antibody, wu:fe05b06 antibody, wu:fe06e10 antibody, zgc:92227 antibody, bone morphogenetic protein receptor type 1A antibody, bone morphogenetic protein receptor, type 1A antibody, bone morphogenetic protein receptor type 1A S homeolog antibody, bone morphogenetic protein receptor, type IAa antibody, bone morphogenetic protein receptor, type IAb antibody, BMPR1A antibody, Bmpr1a antibody, bmpr1a antibody, bmpr1a.S antibody, bmpr1aa antibody, bmpr1ab antibody
Background
The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.