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Beclin 1 antibody (AA 210-239)

BECN1 Reactivity: Human, Mouse WB, FACS, IHC (p) Host: Rabbit Polyclonal RB7463 unconjugated
Catalog No. ABIN388546
  • Target See all Beclin 1 (BECN1) Antibodies
    Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))
    Binding Specificity
    • 16
    • 15
    • 13
    • 9
    • 9
    • 9
    • 8
    • 8
    • 8
    • 8
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 210-239
    Reactivity
    • 195
    • 85
    • 71
    • 9
    • 8
    • 7
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Human, Mouse
    Host
    • 160
    • 38
    • 2
    Rabbit
    Clonality
    • 161
    • 39
    Polyclonal
    Conjugate
    • 90
    • 17
    • 15
    • 14
    • 13
    • 13
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    This Beclin 1 antibody is un-conjugated
    Application
    • 140
    • 94
    • 58
    • 36
    • 29
    • 26
    • 23
    • 22
    • 17
    • 13
    • 12
    • 4
    • 3
    • 2
    Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Predicted Reactivity
    B, Pig, Rat
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This Beclin 1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 210-239 amino acids from human Beclin 1.
    Clone
    RB7463
    Isotype
    Ig Fraction
    Top Product
    Discover our top product BECN1 Primary Antibody
  • Application Notes
    WB: 1:4000. WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Pla, Pascual, Guerri: "Autophagy Constitutes a Protective Mechanism against Ethanol Toxicity in Mouse Astrocytes and Neurons." in: PLoS ONE, Vol. 11, Issue 4, pp. e0153097, (2016) (PubMed).

    Li, Xiong, Shi, Xiao, Qi, Meng: "IKKβ/NFκBp65 activated by interleukin-13 targets the autophagy-related genes LC3B and beclin 1 in fibroblasts co-cultured with breast cancer cells." in: Experimental and therapeutic medicine, Vol. 11, Issue 4, pp. 1259-1264, (2016) (PubMed).

    Jia, Jin, Xiao, Dong, Wang, Fan, Xu, Meng, Li, Lv: "Lipoxin A4 methyl ester alleviates vascular cognition impairment by regulating the expression of proteins related to autophagy and ER stress in the rat hippocampus." in: Cellular & molecular biology letters, Vol. 20, Issue 3, pp. 475-87, (2015) (PubMed).

    Liu, He, von Rütte, Yousefi, Hunger, Simon: "Down-regulation of autophagy-related protein 5 (ATG5) contributes to the pathogenesis of early-stage cutaneous melanoma." in: Science translational medicine, Vol. 5, Issue 202, pp. 202ra123, (2013) (PubMed).

    Dhule, Penfornis, Frazier, Walker, Feldman, Tan, He, Alb, John, Pochampally: "Curcumin-loaded ?-cyclodextrin liposomal nanoparticles as delivery vehicles for osteosarcoma." in: Nanomedicine : nanotechnology, biology, and medicine, Vol. 8, Issue 4, pp. 440-51, (2012) (PubMed).

    Wang, Whiteman, Lian, Wang, Singh, Huang, Denmark: "A non-canonical MEK/ERK signaling pathway regulates autophagy via regulating Beclin 1." in: The Journal of biological chemistry, Vol. 284, Issue 32, pp. 21412-24, (2009) (PubMed).

  • Target
    Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))
    Alternative Name
    Beclin 1 (BECN1 Products)
    Synonyms
    beclin-1 antibody, atg6 antibody, vps30 antibody, beclin1 antibody, Beclin-1 antibody, becn1 antibody, zgc:73097 antibody, ATG6 antibody, VPS30 antibody, 4921513J16Rik antibody, 5430417M23Rik antibody, Atg6 antibody, beclin 1 antibody, beclin 1, autophagy related antibody, beclin 1 protein antibody, beclin-1 antibody, beclin family protein antibody, beclin 1, autophagy related L homeolog antibody, BECN1 antibody, becn1 antibody, atg6 antibody, CpipJ_CPIJ011087 antibody, PTRG_07825 antibody, SJAG_01876 antibody, Becn1 antibody, becn1.L antibody
    Background
    Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). Beclin 1 plays a role in two fundamentally important cell biological pathways: autophagy and apoptosis. Beclin 1 is thought to function as a VPS and autophagy protein as part of a complex with Class III PI3 kinase, Vps34.
    Molecular Weight
    51896
    Gene ID
    8678
    NCBI Accession
    NP_003757
    UniProt
    Q14457
    Pathways
    Autophagy
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