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HTRA1 antibody (N-Term)

HTRA1 Reactivity: Human, Mouse WB, IF, IHC (p) Host: Rabbit Polyclonal RB02326 unconjugated
Catalog No. ABIN388127
  • Target See all HTRA1 Antibodies
    HTRA1 (HtrA Serine Peptidase 1 (HTRA1))
    Binding Specificity
    • 9
    • 8
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 116-147, N-Term
    Reactivity
    • 47
    • 13
    • 11
    • 2
    • 2
    • 2
    • 1
    Human, Mouse
    Host
    • 49
    • 1
    Rabbit
    Clonality
    • 50
    Polyclonal
    Conjugate
    • 22
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This HTRA1 antibody is un-conjugated
    Application
    • 33
    • 25
    • 18
    • 11
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This HtrA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 116-147 amino acids from the N-terminal region of human HtrA1.
    Clone
    RB02326
    Isotype
    Ig Fraction
  • Application Notes
    WB: 1:1000. IF: 1:10~50. WB: 1:2000. IHC-P: 1:10~50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid freeze-thaw cycles.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.
    Expiry Date
    6 months
  • Chamberland, Wang, Jones, Collins-Racie, LaVallie, Huang, Liu, Morris, Flannery, Yang: "Identification of a novel HtrA1-susceptible cleavage site in human aggrecan: evidence for the involvement of HtrA1 in aggrecan proteolysis in vivo." in: The Journal of biological chemistry, Vol. 284, Issue 40, pp. 27352-9, (2009) (PubMed).

  • Target
    HTRA1 (HtrA Serine Peptidase 1 (HTRA1))
    Alternative Name
    HtrA1 (HTRA1 Products)
    Background
    HtrA1 a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth.
    Molecular Weight
    51287
    Gene ID
    5654
    NCBI Accession
    NP_002766
    UniProt
    Q92743
    Pathways
    Growth Factor Binding
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