Drosophila SUMO (AA 37-66) antibody

Catalog No. ABIN388088

Product Details

Target: Drosophila SUMO

Binding Specificity: AA 37-66

Reactivity: Drosophila melanogaster

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This Drosophila SUMO antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37-66 amino acids of Drosophila SUMO.

Clone: RB3488

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References

Maarifi, Hannoun, Geoffroy, El Asmi, Zarrouk, Nisole, Blondel, Chelbi-Alix: "MxA Mediates SUMO-Induced Resistance to Vesicular Stomatitis Virus." in: Journal of virology, Vol. 90, Issue 14, pp. 6598-6610, (2017) (PubMed).

Kearse, Ireland, Prem, Chen, Ware: "RpL22e, but not RpL22e-like-PA, is SUMOylated and localizes to the nucleoplasm of Drosophila meiotic spermatocytes." in: Nucleus (Austin, Tex.), Vol. 4, Issue 3, pp. 241-58, (2013) (PubMed).

Sahota, Grau, Mansilla, Ferrús: "Troponin I and Tropomyosin regulate chromosomal stability and cell polarity." in: Journal of cell science, Vol. 122, Issue Pt 15, pp. 2623-31, (2009) (PubMed).

Target Details

Target: Drosophila SUMO

Background: Covalent modification of target lysines by SUMO (small ubiquitin-like modifier) modulates processes such as protein localization, transcription, nuclear transport, mitosis, DNA replication and repair, signal transduction, and viral reproduction. SUMO does not seem to be involved in protein degradation and may in fact function as an antagonist of ubiquitin in the degradation process. In the development of Drosophila, SUMO plays a maternal role in anterior-posterior (A/P) polarity and patterning.

Molecular Weight: 10124

Gene ID: 33981

UniProt: O97102