CBLC antibody (C-Term)

Catalog No. ABIN388072

Product Details anti-CBLC Antibody

Target: CBLC (Cbl proto-oncogene C (CBLC))

Binding Specificity: AA 424-453, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CBLC antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This CBLC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 424-453 amino acids from the C-terminal region of human CBLC.

Clone: RB0696

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for CBLC

Target: CBLC (Cbl proto-oncogene C (CBLC))

Alternative Name: CBLC (CBLC Products)

Synonyms: CBL-3 antibody, CBL-SL antibody, RNF57 antibody, Cbl proto-oncogene C antibody, CBLC antibody, Cblc antibody

Background: Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.

Molecular Weight: 52456

Gene ID: 23624

NCBI Accession: NP_001124324, NP_036248

UniProt: Q9ULV8

Pathways: EGFR Signaling Pathway