KDM3A antibody (N-Term)

Catalog No. ABIN387995

Product Details anti-KDM3A Antibody

Target: KDM3A (Lysine (K)-Specific Demethylase 3A (KDM3A))

Binding Specificity: AA 50-79, N-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KDM3A antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This JHDM2a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 50-79 amino acids from the N-terminal region of human JHDM2a.

Clone: RB14307

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for KDM3A

Target: KDM3A (Lysine (K)-Specific Demethylase 3A (KDM3A))

Alternative Name: JHDM2a (KDM3A Products)

Synonyms: JHDM2A antibody, JHMD2A antibody, JMJD1 antibody, JMJD1A antibody, TSGA antibody, tsga antibody, jmjd1 antibody, jhdm2a antibody, jhmd2a antibody, jmjd1a antibody, 1700105C21Rik antibody, C230043E16Rik antibody, JHDM2a antibody, Jmjd1 antibody, Jmjd1a antibody, KDM2A antibody, TGSA antibody, Tsga antibody, mKIAA0742 antibody, KDM3A antibody, kdm3a antibody, lysine demethylase 3A antibody, lysine (K)-specific demethylase 3A antibody, lysine-specific demethylase 3A antibody, lysine (K)-specific demethylase 3A S homeolog antibody, KDM3A antibody, kdm3a antibody, Kdm3a antibody, LOC100453519 antibody, kdm3a.S antibody

Background: JHDM2a is a zinc finger protein that contains a jumonji domain. It is a histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. This protein preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. It is involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation.

Molecular Weight: 147341

Gene ID: 55818

NCBI Accession: NP_001140160, NP_060903

UniProt: Q9Y4C1

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding, Warburg Effect