ATG12 antibody (N-Term)
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- Target See all ATG12 Antibodies
- ATG12 (Autophagy Related 12 (ATG12))
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Binding Specificity
- AA 8-38, N-Term
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This ATG12 antibody is un-conjugated
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Application
- Immunofluorescence (IF)
- Purification
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- Immunogen
- This ATG12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8-38 amino acids from the N-terminal region of human ATG12.
- Clone
- RB2793
- Isotype
- Ig Fraction
- Top Product
- Discover our top product ATG12 Primary Antibody
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- Application Notes
- IF: 1:50~100
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
- Expiry Date
- 6 months
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Immunohistochemical evidence for macroautophagy in neurones and endothelial cells in Alzheimer's disease." in: Neuropathology and applied neurobiology, Vol. 36, Issue 4, pp. 312-9, (2010) (PubMed).
: "
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Immunohistochemical evidence for macroautophagy in neurones and endothelial cells in Alzheimer's disease." in: Neuropathology and applied neurobiology, Vol. 36, Issue 4, pp. 312-9, (2010) (PubMed).
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- Target
- ATG12 (Autophagy Related 12 (ATG12))
- Alternative Name
- ATG12 (ATG12 Products)
- Background
- Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). APG12L is the human homolog of yeast APG12, a ubiquitin-activating enzyme E1-like protein essential for the conjugation system that mediates membrane fusion in autophagy.
- Molecular Weight
- 15113
- Gene ID
- 9140
- NCBI Accession
- NP_001264712, NP_004698
- UniProt
- O94817
- Pathways
- Autophagy
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