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MLL/KMT2A antibody (C-Term)

MLL Reactivity: Human FACS, IHC (p) Host: Rabbit Polyclonal RB02951 unconjugated
Catalog No. ABIN387979
  • Target See all MLL/KMT2A (MLL) Antibodies
    MLL/KMT2A (MLL) (Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL))
    Binding Specificity
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 3879-3908, C-Term
    Reactivity
    • 23
    • 12
    • 9
    Human
    Host
    • 18
    • 5
    Rabbit
    Clonality
    • 19
    • 4
    Polyclonal
    Conjugate
    • 16
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MLL/KMT2A antibody is un-conjugated
    Application
    • 11
    • 9
    • 8
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This HRX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3879-3908 amino acids from the C-terminal region of human HRX.
    Clone
    RB02951
    Isotype
    Ig Fraction
    Top Product
    Discover our top product MLL Primary Antibody
  • Application Notes
    IHC-P: 1:50~100. FC: 1:10~50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Target
    MLL/KMT2A (MLL) (Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL))
    Alternative Name
    HRX (MLL Products)
    Synonyms
    ALL-1 antibody, CXXC7 antibody, HRX antibody, HTRX1 antibody, MLL antibody, MLL/GAS7 antibody, MLL1A antibody, TET1-MLL antibody, TRX1 antibody, WDSTS antibody, 6430520K01 antibody, All1 antibody, Cxxc7 antibody, Mll antibody, Mll1 antibody, mKIAA4050 antibody, lysine methyltransferase 2A antibody, lysine (K)-specific methyltransferase 2A antibody, KMT2A antibody, Kmt2a antibody
    Background
    The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia. Tse et al. (1995) characterized 2 t(1,11)(q21,q23) translocations that fused the MLL gene to a gene on chromosomal band 1q21, AF1Q, in 2 infants with acute myelomonocytic leukemia. In one of these patients, the derivative chromosome 11 represented an in-frame fusion of the N-terminal portion of the MLL gene to the complete AF1Q open reading frame, whereas the derivative chromosome 1 did not give rise to an open reading frame. This observation suggested that the N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23.
    Molecular Weight
    431764
    Gene ID
    4297
    NCBI Accession
    NP_001184033, NP_005924
    UniProt
    Q03164
    Pathways
    Warburg Effect
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