HAT1 antibody (C-Term)

Catalog No. ABIN387932

Product Details anti-HAT1 Antibody

Target: HAT1 (Histone Acetyltransferase 1 (HAT1))

Binding Specificity: AA 389-419, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HAT1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Predicted Reactivity: M, Rat

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This KAT1 (HAT1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 389-419 amino acids from the C-terminal region of human KAT1 (HAT1).

Clone: RB5769

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:100. IHC-P: 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for HAT1

Target: HAT1 (Histone Acetyltransferase 1 (HAT1))

Alternative Name: KAT1 (HAT1) (HAT1 Products)

Synonyms: KAT1 antibody, HAC07 antibody, HAC7 antibody, HAG02 antibody, MIK19.19 antibody, MIK19_19 antibody, histone acetyltransferase of the GNAT family 2 antibody, hac106 antibody, hat1 antibody, zgc:92639 antibody, histone acetyltransferase 1 antibody, histone acetyltransferase of the GNAT family 2 antibody, histone acetyltransferase catalytic subunit antibody, histone acetyltransferase Hat1 antibody, histone acetyltransferase 1 L homeolog antibody, HAT1 antibody, Hat1 antibody, HAG2 antibody, hat1 antibody, hat1.L antibody

Background: Histone acetylation, particularly of histone H4, has been proposed to play an important role in replication-dependent nucleosome assembly. The HAT1 protein contains D, A, and B motifs, which are present in many N-acetyltransferases, including those that acetylate substrates other than histones. The HAT1 holoenzyme consists of 2 subunits: the catalytic 46-kD HAT1 and the accessory p46. The p46 subunit stimulated the activity of HAT1 and bound to core histones. The HAT1 holoenzyme acetylated newly synthesized but not nucleosomal histone H4 at lys5 and lys12, and, to a lesser extent, histone H2A at lys5. HAT1 and p46 polypeptides are located in the nucleus of S-phase cells. HAT1 may play a role in telomeric silencing.

Molecular Weight: 49513

Gene ID: 8520

NCBI Accession: NP_003633

UniProt: O14929