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LRRK2 antibody (C-Term)
LRRK2
Reactivity: Human, Mouse
Host: Mouse
Monoclonal
133AT1218
unconjugated
Product Details anti-LRRK2 Antibody
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Target
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LRRK2
(Leucine-Rich Repeat Kinase 2 (LRRK2))
Binding Specificity
All epitopes for LRRK2 antibodies
C-Term
Reactivity
All reactivities for LRRK2 antibodies
Human, Mouse
Host
All hosts for LRRK2 antibodies
Mouse
Clonality
All clonalities for LRRK2 antibodies
Monoclonal
Conjugate
All conjugates for LRRK2 antibodies
This LRRK2 antibody is un-conjugated
Application
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Purification
This antibody is purified through a protein G column, followed by dialysis against PBS.
Immunogen
This PARK8 (LRRK2) antibody was raised in mice using purified His-tagged recombinant protein comprised of the C-terminal 261 residues of LRRK2.
Clone
133AT1218
Isotype
IgG1
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Alternatives
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Application Details
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Application Notes
IHC: 1:50
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Storage Comment
Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date
6 months
References for anti-LRRK2 antibody (ABIN387804)
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Ortiz-Ortiz, Morán, Ruiz-Mesa, Niso-Santano, Bravo-SanPedro, Gómez-Sánchez, González-Polo, Fuentes : "Curcumin exposure induces expression of the Parkinson's disease-associated leucine-rich repeat kinase 2 (LRRK2) in rat mesencephalic cells. " in: Neuroscience letters , Vol. 468 , Issue 2 , pp. 120-4 , (2009 ) (PubMed ).
Biskup, Moore, Rea, Lorenz-Deperieux, Coombes, Dawson, Dawson, West : "Dynamic and redundant regulation of LRRK2 and LRRK1 expression. " in: BMC neuroscience , Vol. 8 , pp. 102 , (2008 ) (PubMed ).
Target Details for LRRK2
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Target
LRRK2
(Leucine-Rich Repeat Kinase 2 (LRRK2))
Alternative Name
PARK8 (LRRK2) (LRRK2 Products )
Synonyms
LRRK2 antibody, AURA17 antibody, DARDARIN antibody, PARK8 antibody, RIPK7 antibody, ROCO2 antibody, 4921513O20Rik antibody, 9330188B09Rik antibody, AW561911 antibody, D630001M17Rik antibody, Gm927 antibody, cI-46 antibody, leucine-rich repeat kinase 2 antibody, leucine rich repeat kinase 2 antibody, lrrk2 antibody, LRRK2 antibody, Lrrk2 antibody
Background
This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8.
Molecular Weight
286103
Gene ID
120892
NCBI Accession
NP_940980
UniProt
Q5S007
Pathways
Regulation of G-Protein Coupled Receptor Protein Signaling , Skeletal Muscle Fiber Development
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