Caspase 3 antibody

Catalog No. ABIN379633

Product Details anti-Caspase 3 Antibody

Target: Caspase 3 (CASP3)

Reactivity: Human, Mouse, Rat, Cow, Dog, Monkey, Pig, Rabbit, Hamster, Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Caspase 3 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: Reacts with active form of caspase 3 (17 kD protein). Caspase 3 is a member of the interleukin-1 beta-converting enzyme family. Caspase 3 is though to be associated with induction of apoptosis. Caspase 3 is synthesized as inactive 32 kD proenzyme and is processed during apoptosis generating two subunits of 17 kD and 12 kD. Caspase 3 stains the epithelial cells of skin, renal proximal tubules and collecting ducts. This antibody cross reacts with mouse, rat, monkey, rabbit, hamster, cow, sheep, pig and dog.

Purification: Ig fraction

Immunogen: Recombinant full-length human Caspase 3 protein.

Type of Immunogen: Recombinant protein

Application Details

Application Notes: Approved: IHC, IHC-P (1:50 - 1:100)

Usage: FFPE tissue sections require high temperature antigen unmasking with 10 mM citrate buffer,  pH 6.0 prior to immunostaining.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Antiserum, sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2-8°C. Do not freeze.

Target Details for Caspase 3

Target: Caspase 3 (CASP3)

Alternative Name: CASP3 / Caspase 3 (CASP3 Products)

Background: Name/Gene ID: CASP3
Subfamily: Cysteine C14
Family: Protease

Synonyms: CASP3, Apopain, CASP-3, Caspase-3, CPP32B, CPP32, Cysteine protease CPP32, SCA-1, SREBP cleavage activity 1, Yama, Procaspase3, Caspase 3, CPP-32, PARP cleavage protease, Protein Yama

Gene ID: 836

Pathways: Apoptosis, Caspase Cascade in Apoptosis, Sensory Perception of Sound, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Activated T Cell Proliferation