MSH6 antibody
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- Target See all MSH6 Antibodies
- MSH6 (MutS Homolog 6 (E. Coli) (MSH6))
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Reactivity
- Human, Mouse, Rat, Dog
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This MSH6 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunoprecipitation (IP)
- Specificity
- MSH6 is a heterodimer of MSH2 and binds to DNA containing G/T mismatches. The MSH2-MSH6 complex recognizes a single-based mispair insertion/deletion loop. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related human carcinogenesis. Studies have shown the mutations of MLH-1, MSH2 and MSH6 genes contribute to the development of sporadic colorectal carcinoma. The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. cross reacts with mouse, rat and dog.
- Purification
- Purified
- Immunogen
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Synthetic human MSH6 peptide.
Type of Immunogen: Synthetic peptide - Clone
- 44
- Isotype
- IgG1
- Top Product
- Discover our top product MSH6 Primary Antibody
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- Application Notes
- Approved: IP, WB (1:100 - 1:500)
- Comment
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Target Species of Antibody: Human
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Buffer contains: 0.05 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Storage Comment
- Store at 2-8°C. Do not freeze.
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- Target
- MSH6 (MutS Homolog 6 (E. Coli) (MSH6))
- Alternative Name
- MSH6 (MSH6 Products)
- Synonyms
- GTBP antibody, GTMBP antibody, HNPCC5 antibody, HSAP antibody, p160 antibody, cb326 antibody, wu:fb36c12 antibody, LOC100227810 antibody, AU044881 antibody, AW550279 antibody, Gtmbp antibody, mutS homolog 6 antibody, mutS homolog 6 (E. coli) antibody, DNA mismatch repair protein antibody, MSH6 antibody, msh6 antibody, Msh6 antibody
- Background
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Name/Gene ID: MSH6
Synonyms: MSH6, GTBP, HSAP, GTMBP, MutS (E. coli) homolog 6, HMSH6, Sperm-associated protein, p160, G/T mismatch-binding protein, HNPCC5, MutS homolog 6 (E. coli), MutS-alpha 160 kDa subunit - Gene ID
- 2956
- Pathways
- DNA Damage Repair, Chromatin Binding, Production of Molecular Mediator of Immune Response
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