TIMP4 antibody (AA 35-224)

Catalog No. ABIN375604

Product Details anti-TIMP4 Antibody

Target: TIMP4 (TIMP Metallopeptidase Inhibitor 4 (TIMP4))

Binding Specificity: AA 35-224

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TIMP4 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: Human/Mouse/Rat TIMP-4

Characteristics: Mouse Anti-Human TIMP-4-UNLB

Purification: Purified

Immunogen: Recombinant human TIMP-4 (a.a. 35-224)

Clone: SB30c

Isotype: IgG2a

Application Details

Application Notes:

• Applications: WB - Quality tested , ICC , ELISA
• Working Dilutions: Immunoblotting Purified (UNLB) antibody ≤ 2 g/mL HRP conjugate 1:1,000 - 1:2,000

Sample Volume: 0,2 mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: 0.1 mg purified immunoglobulin in 0.2 mL of borate buffered saline,  pH 8.2. No preservatives or amine-containing buffer salts added

Preservative: Without preservative

Handling Advice: Each reagent is stable for the period shown on the bottle label if stored as directed.

Storage: 4 °C

Storage Comment: Store at 2-8°C

Target Details for TIMP4

Target: TIMP4 (TIMP Metallopeptidase Inhibitor 4 (TIMP4))

Alternative Name: TIMP-4 (TIMP4 Products)

Synonyms: TIMP4 antibody, TIMP-4 antibody, timp4 antibody, TIMP metallopeptidase inhibitor 4 antibody, TIMP metallopeptidase inhibitor 4, tandem duplicate 3 antibody, tissue inhibitor of metalloproteinase 4 antibody, TIMP4 antibody, timp4.3 antibody, Timp4 antibody

Background: Tissue inhibitors of matrix metalloproteinases (TIMPs) constitute a family of secreted multifunctional proteins which are classified based on structural similarity to each other as well as their ability to inhibit matrix metalloproteinases (MMPs). TIMPs therefore play a critical role in ECM homeostasis but have also been shown to have erythroid-potentiating and cell growth-promoting activities. TIMP-4 (approx. 23 kDa), unlike TIMP-1, TIMP-2 and TIMP-3, shows restricted localization to cardiac, neural, breast and muscle tissue. Cardiospecific TIMP-4 seems to play a significant role in regulating the normal cell phenotype since reduced levels elicit cellular transformation. It has been shown to be an inhibitor of MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9 with a preference for MMP-2 and MMP-7.