LAMP2 antibody (PE)

Catalog No. ABIN375530

Product Details anti-LAMP2 Antibody (PE)

Target: LAMP2 (Lysosomal-Associated Membrane Protein 2 (LAMP2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This LAMP2 antibody is conjugated to PE

Application: Immunohistochemistry (IHC), Flow Cytometry (FACS)

Specificity: Human/Rhesus/African Green Monkey CD107b, Mr 100-120 kDa

Characteristics: Mouse Anti-Human CD107b-PE

Purification: Purified

Immunogen: Human adherent peripheral blood cells

Clone: H4B4

Isotype: IgG1

Application Details

Application Notes: Working Dilution:
10 µL/10^6 cells
Representative data are included in this product insert.

Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.

Restrictions: For Research Use only

Handling

Handling Advice: Do not freeze!
Protect conjugated products from light.
Each reagent is stable for the period shown on the bottle label if stored as directed.

Storage: 4 °C

Target Details for LAMP2

Target: LAMP2 (Lysosomal-Associated Membrane Protein 2 (LAMP2))

Alternative Name: CD107b (LAMP2 Products)

Synonyms: CD107b antibody, LAMP-2 antibody, LAMPB antibody, LGP110 antibody, Lamp-2 antibody, Lamp-2a antibody, Lamp-2b antibody, Lamp-2c antibody, Mac3 antibody, cd107b antibody, lamp-2 antibody, lampb antibody, LAMP2 antibody, lamp2 antibody, DKFZp459J126 antibody, LGP-B antibody, sb:cb587 antibody, wu:fb14a06 antibody, zgc:103532 antibody, lysosomal associated membrane protein 2 antibody, lysosomal-associated membrane protein 2 antibody, lysosomal-associated membrane protein 2 S homeolog antibody, lysosomal membrane glycoprotein 2 antibody, LAMP2 antibody, Lamp2 antibody, lamp2.S antibody, lamp2 antibody

Background: CD107b, also known as lysosomal-associated membrane protein 2 (LAMP-2), is a heavily glycosylated, type I transmembrane protein that constitutes the major sialoglycoproteins on lysosomal membranes. It is a ligand for galaptin, an S-type lectin present in extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains, and is a ligand for E-selectin-mediated cell adhesion. CD107b is expressed by granulocytes, T cells, macrophages, dendritic cells, activated platelets tonsillar epithelium and some tumor cell lines, including U937 and KG1a. It is also a widely expressed intracellular antigen. LAMP-2 may function in protecting the inner surface of the lysosomal membrane by forming a barrier to lysosomal hydrolases. The upregulation of both CD107a and CD107b on the surface of tumor cell lines has been associated with their enhanced metastatic potential, where they may increase adhesion to extracellular matrix and endothelium.

Pathways: Autophagy