MBNL1 antibody (C-Term)
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- Target See all MBNL1 Antibodies
- MBNL1 (Muscleblind-like Protein 1 (MBNL1))
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Binding Specificity
- C-Term
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Reactivity
- Human, Rat, Mouse, Dog, Cow
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Host
- Goat
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Clonality
- Polyclonal
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Conjugate
- This MBNL1 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Specificity
- This antibody reacts to MBNL1.
- Cross-Reactivity (Details)
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Species reactivity (expected):Mouse, Rat, Canine, Bovine.
Species reactivity (tested):Human. - Purification
- Affinity chromatography
- Immunogen
- Peptide with sequence C-SAEHLTSHKYVTQ, from the C Terminus of the protein sequence
- Top Product
- Discover our top product MBNL1 Primary Antibody
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- Application Notes
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Peptide ELISA: 1/4000. Western Blot: 1 - 3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 0,5 mg/mL
- Buffer
- Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Target
- MBNL1 (Muscleblind-like Protein 1 (MBNL1))
- Alternative Name
- MBNL1 (MBNL1 Products)
- Synonyms
- MBNL1 antibody, zgc:153954 antibody, Mbnl antibody, mKIAA0428 antibody, EXP antibody, EXP35 antibody, EXP40 antibody, EXP42 antibody, MBNL antibody, muscleblind like splicing regulator 1 antibody, muscleblind-like splicing regulator 1 antibody, muscleblind like splicing factor 1 antibody, MBNL1 antibody, mbnl1 antibody, Mbnl1 antibody
- Background
- Muscleblind 1 (MBNL1) binds to the CUG triplet expansion in dsRNA. It appears to play a role in RNA splicing. Several important human diseases are associated with expansion of polynucleotide sequences, in most cases trinucleotide repeats. Myotonic dystrophy (DM1) is one of these diseases, and is associated with increases in the number of CTG repeats in the 3' UTR of the gene encoding myotonin (a.k.a. DM Kinase, DMK or myotonin-Protein Kinase), a ser/thr kinase expressed specifically in muscle. Mammalian genomes contain three muscleblind-like proteins, generally referred to as MBNL1, MBNL2 and MBNL3, and all three were found to associate with long double stranded CUG RNA repeats, thus being triplet repeat expansion dsRNA-binding proteins.Synonyms: EXP, Muscleblind-like protein 1
- Gene ID
- 4154, 9606
- UniProt
- Q9NR56
- Pathways
- Ribonucleoprotein Complex Subunit Organization
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