PDE11A antibody (Internal Region)
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- Target See all PDE11A Antibodies
- PDE11A (phosphodiesterase 11A (PDE11A))
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Binding Specificity
- Internal Region
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Reactivity
- Human, Mouse, Rat, Dog
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Host
- Goat
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Clonality
- Polyclonal
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Conjugate
- This PDE11A antibody is un-conjugated
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Application
- Western Blotting (WB)
- Specificity
- This antibody reacts to PDE11A.
- Cross-Reactivity (Details)
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Species reactivity (expected):Mouse, Rat, Canine.
Species reactivity (tested):Human. - Purification
- Affinity chromatography
- Immunogen
- Peptide with sequence C-NSFKESMEKSSYSD, from the internal region of the protein sequence
- Top Product
- Discover our top product PDE11A Primary Antibody
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- Application Notes
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Peptide ELISA: 1/2000. Western Blot: 0.5 - 1.5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Target
- PDE11A (phosphodiesterase 11A (PDE11A))
- Alternative Name
- PDE11A (PDE11A Products)
- Synonyms
- PPNAD2 antibody, 6330414F14Rik antibody, A630086N24Rik antibody, Gm350 antibody, PDE11A1 antibody, si:ch211-222f23.5 antibody, PDE11A antibody, ppnad2 antibody, Pde11a antibody, phosphodiesterase 11A antibody, phosphodiesterase 11a antibody, dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A antibody, PDE11A antibody, Pde11a antibody, pde11a antibody, LOC100470038 antibody
- Background
- One of the many phosphodiesterases that compartmentalize and hydrolyze cAMP and cGMP into AMP and GMP is Phosphodiesterase type 11. The human PDE11A contains an open reading frame encoding a 490 amino acid protein (55-56 kDa). The PDE11A has an N terminus GAF domain homologous to other signaling molecule as found in PDE2, PDE5, PDE6, PDE10, which potentially represents an allosteric cGMP and other small signaling molecules. PDE11A hydrolyzes both cGMP and cAMP, it is sensitive to non selective PDE inhibitor IBMX as well as zaprinast and dipyrimadole inhibitors that are generally selective for cGMP specific enzymes. PDE11A expression is diverse and is found in high levels in skeletal muscle, prostate, kidney, liver, pituitary and testis. There are several isoforms known: Isoform 1 is present in prostate, pituitary, heart and liverbut not in testis or in penis. Isoform 2 is believed to be expressed in testis and Isoform 4 in the adrenal cortex.Synonyms: 5'-cyclic-AMP and -GMP phosphodiesterase 11A, Dual 3', PDE11A1, PDE11A2, PDE11A3, PDE11A4, Phosphodiesterase 11A, cAMP and cGMP phosphodiesterase 11A
- Gene ID
- 50940
- NCBI Accession
- NP_001070664
- UniProt
- Q9HCR9
- Pathways
- cAMP Metabolic Process
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