SDCBP antibody (N-Term)

Catalog No. ABIN374747

Product Details anti-SDCBP Antibody

Target: SDCBP (Syndecan Binding Protein (Syntenin) (SDCBP))

Binding Specificity: N-Term

Reactivity: Human, Rat, Mouse, Dog

Host: Goat

Clonality: Polyclonal

Conjugate: This SDCBP antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody is expected to recognise isoform 1 (NP_005616.2 and NP_001007068.1) and isoform 3 (NP_001007070.1and NP_001007071.1) only.

Cross-Reactivity (Details): Species reactivity (expected):Mouse, Rat, Canine.
Species reactivity (tested):Human.

Purification: Ammonium Sulphate precipitation followed by Antigen Affinity Chromatography using the immunizing peptide

Immunogen: Peptide with sequence from the N-Terminus of Human Syntenin-1 / SDCBP (NP_005616.2, NP_001007068.1, NP_001007069, NP_001007070.1, NP_001007071.1). Genename: SLEDLKVDKVIQAQ-C

Application Details

Application Notes: Peptide ELISA: 1/128000. Western Blot: 0.01 - 0.03 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for SDCBP

Target: SDCBP (Syndecan Binding Protein (Syntenin) (SDCBP))

Alternative Name: Syntenin-1 / SDCBP (SDCBP Products)

Background: Syntenin is an approximately 33 kDa scaffolding protein that that binds to kainate receptor subunits via a PDZ interaction. Syntenin has a tightly regulated developmental profile in neurons and is most abundant in the period of intense growth and synapse formation and stabilization (Hirbec et al, 2005). There is extensive colocalization of syntenin and kainate receptors with particularly intense labeling for both proteins at growth cones. It is proposed that syntenin has a role both in controlling membrane organization and in determining the formation and maturation of synapses.Synonyms: MDA-9, MDA9, Melanoma differentiation-associated protein 9, Pro-TGF-alpha cytoplasmic domain-interacting protein 18, SYCL, Scaffold protein Pbp1, Syndecan-binding protein 1, TACIP18

Gene ID: 6386

NCBI Accession: NP_001007068

UniProt: O00560