Fibulin 5 antibody (C-Term, Internal Region)

Catalog No. ABIN374733

Product Details anti-Fibulin 5 Antibody

Target: Fibulin 5 (FBLN5)

Binding Specificity: C-Term, Internal Region

Reactivity: Human, Mouse, Rat, Dog

Host: Goat

Clonality: Polyclonal

Conjugate: This Fibulin 5 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: This antibody reacts to FBLN5.

Cross-Reactivity (Details): Species reactivity (expected):Mouse, Rat, Canine.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Immunogen: Peptide with sequence C-RPIKGPREIQLDLE, from the internal region (near the C Terminus) of the protein sequence

Application Details

Application Notes: Peptide ELISA: 1/32000. Western Blot: 0.1 - 0.3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for Fibulin 5

Target: Fibulin 5 (FBLN5)

Alternative Name: Fibulin-5 (FBLN5 Products)

Background: Fibulin 5(FBLN5), the active form of which is about 66 kDa (unprocessed precursor 50 kDa), is a recently discovered multifunctional extracellular matrix protein that mediates endothelial cell adhesion through integrin ligation, regulates cell growth and motility in a context-specific manner, and prevents elastinopathy in vivo. Fibulin-5 is abundantly expressed in great vessels and cardiac valves during embryogenesis, and in many adult tissues including the aorta, lung, uterus and skin, all of which contain abundant elastic fibres. Decreased fibulin 5 may contribute to the pathogenesis of aortic dissection by impairing elastic fiber assembly. Fibulin 5 is also a good marker of skin ageing and that the earlier loss of fibulin 5 may involve age-dependent changes in other elastic fibre components.Synonyms: DANCE, Developmental arteries and neural crest EGF-like protein, FBLN5, FIBL-5, UP50, Urine p50 protein

Gene ID: 10516

NCBI Accession: NP_006320

UniProt: Q9UBX5

Pathways: SARS-CoV-2 Protein Interactome