AKR1C4 antibody (N-Term)

Catalog No. ABIN374680

Product Details anti-AKR1C4 Antibody

Target: AKR1C4 (Aldo-keto Reductase Family 1 Member C4 (AKR1C4))

Binding Specificity: N-Term

Reactivity: Human

Host: Goat

Clonality: Polyclonal

Conjugate: This AKR1C4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: This antibody reacts to AKR1C4 / DDH4. This antibody may cross-react with AKR1C1.

Purification: Affinity chromatography

Immunogen: Peptide with sequence DPKYQRVELNDGH-C, from the N Terminus of the protein sequence

Application Details

Application Notes: Peptide ELISA: 1/4000. Western Blot: 0.1 - 0.3 μg/mL. Immunohistochemistry on paraffin sections: 2 - 4 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for AKR1C4

Target: AKR1C4 (Aldo-keto Reductase Family 1 Member C4 (AKR1C4))

Alternative Name: AKR1C4 (AKR1C4 Products)

Background: HSD3a catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3alpha,17beta-diol (3-alpha-diol). Also has some 20-alpha-hydroxysteroid dehydrogenase activity.Synonyms: 3-alpha-HSD1, 3-alpha-hydroxysteroid dehydrogenase type I, Aldo-keto reductase family 1 member C4, CDR, CHDR, Chlordecone reductase, DD-4, DD4, Dihydrodiol dehydrogenase 4, HAKRA

Gene ID: 1109, 9606

UniProt: P17516

Pathways: Steroid Hormone Biosynthesis