PUM2
Reactivity: Human, Mouse, Rat, Dog, Horse, Rabbit, Cow, Pig, Guinea Pig, Bat
WB
Host: Rabbit
Polyclonal
unconjugated
Application Notes
Peptide ELISA: 1/4000. Western Blot: 1 - 3 μg/mL, Some minor bands are resistant to blocking by the immunizingpeptide. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
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Background
Pumilio 2, a human homolog of Pumilio, a protein required to maintain germ line stem cells in Drosophila and Caenorhabditis elegans, forms a stable complex with DAZ through the same functional domain required for RNA binding, protein-protein interactions and rescue of Pumilio mutations in flies. Pumilio 2 is expressed predominantly in human embryonic stem cells and germ cells and colocalizes with DAZ and DAZL in germ cells. Pumilio 2 is a component of conserved cellular machinery that may be required for germ cell development.Synonyms: KIAA0235, PUM-2, PUMH2, Pumilio homolog 2, Pumilio-2